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zolpidem (Ambien)

an azabicyclo(4.3.0)nonane; a nonbenzodiazepine; benzodiazepine receptor agonist; RN given from Toxline; RN not in Chemline 12/85; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; structure given in first source

Also Known As:

Ambien; Stilnox; zolpidem tartrate; 1A brand of zolpidem tartrate; AWD brand of zolpidem tartrate; AbZ brand of zolpidem tartrate; Allphar brand of zolpidem tartrate; Amsic; Atlanta Pharma brand of zolpidem tartrate; BC brand of zolpidem tartrate; Bikalm; Dalparan; Farma Lepori brand of zolpidem tartrate; Hexal brand of zolpidem tartrate; Krewel brand of zolpidem tartrate; Lichtenstein brand of zolpidem tartrate; Merck dura brand of zolpidem tartrate; N,N,6-trimethyl-2-(4-methylphenyl)imidazo(1,2a)pyridine-3-acetamide hemitartrate; SL 80.0750; SL-800750-23-N; Sanofi Synthelabo brand of zolpidem tartrate; Sanofi brand of zolpidem tartrate; Stilnoct; Zoldem; Zolirin; Zolpi-Lich; Zolpidem 1A Pharma; Zolpidem AbZ; Zolpinox; zodormdura

Networked: 572 relevant articles (71 outcomes, 113 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyridines: 41
    - zolpidem: 572

Experts

1.	Roth, Thomas: 13 articles (01/2014 - 08/2006)
2.	Kao, Chia-Hung: 9 articles (09/2015 - 05/2012)
3.	Walsh, James K: 7 articles (11/2010 - 10/2002)
4.	Sung, Fung-Chang: 6 articles (01/2015 - 05/2012)
5.	Clauss, R P: 6 articles (10/2012 - 01/2000)
6.	Gottschlich, Michele M: 5 articles (05/2015 - 01/2008)
7.	Kagan, Richard J: 5 articles (05/2015 - 01/2008)
8.	Lin, Cheng-Li: 4 articles (09/2015 - 01/2015)
9.	Lin, Che-Chen: 4 articles (05/2015 - 05/2013)
10.	Gosseries, Olivia: 4 articles (01/2014 - 01/2013)

Related Diseases

1.	Sleep Initiation and Maintenance Disorders (Insomnia) 01/01/2010 - "Zolpidem is clinically very effective in treating insomnia. " 05/18/2007 - "Zolpidem has been known as a very safe and effective hypnotic drug used to treat a variety of patients with insomnia. " 08/01/2004 - "Over a period of 12 weeks of intermittent treatment with zolpidem, sleep continuity was significantly improved, the clinical gains were sustained, and there was no evidence of subjective rebound insomnia between doses or increases in the amount of medication used during the study interval." 10/01/2008 - "Employed adults with chronic insomnia treated with zolpidem extended-release 12.5 mg experienced significantly improved work performance over 24 weeks." 12/15/2000 - "In agreement with previous findings obtained in patients with chronic primary insomnia, zolpidem significantly improved sleep induction and maintenance. "
2.	Brain Injuries (Brain Injury) 08/01/2004 - "The authors postulate a central mechanism of action by selective inhibition of GABAergic inhibitory neurons, and suggest a controlled clinical study to investigate the potential efficacy of zolpidem in relieving spasticity related to postanoxic brain injury." 01/01/2004 - "After zolpidem, cerebral perfusion through brain injury areas improved substantially in three patients and the cerebellar diaschisis was reversed. " 01/01/2008 - "This study treated a 44 year old male with MCS some 4 years after his traumatic brain injury with zolpidem for 1 week on and 1 week off treatment. " 01/01/2004 - "The study investigates the effect of zolpidem (CAS 82626-48-0) on brain injuries and cerebellar diaschisis. " 01/01/2013 - "Characteristic changes in brain activity accompany the paradoxical increase in alertness observed in some patients with severe brain injury when they are treated with the sleeping pill zolpidem. "
3.	Persistent Vegetative State (Vegetative State) 10/01/2010 - "The aim of this study was to determine if zolpidem is associated with improved responsiveness or regional cerebral perfusion in patients with persistent vegetative states. " 01/01/2006 - "The long term efficacy of zolpidem in the permanent vegetative state is described in three patients. " 01/01/2014 - "To study the Zolpidem arousing effect in persistent vegetative state (PVS) patients combining clinical evaluation, autonomic assessment by heart rate variability (HRV), and EEG records. " 10/01/2010 - "Zolpidem for persistent vegetative state--a placebo-controlled trial in pediatrics." 02/01/2015 - "Transient awakening from vegetative state: is high-dose zolpidem more effective?"
4.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/01/2014 - "After abrupt discontinuation of zolpidem, 570 mg per day, she exhibited severe withdrawal symptoms, led her to be admitted to emergency department. " 03/01/2011 - "Several recent reports attest to zolpidem's strong potential for abuse, dependence, and severe withdrawal symptoms upon its discontinuation. " 09/01/2004 - "A case of parenteral zolpidem dependence with opioid-like withdrawal symptoms." 08/30/1993 - "Adverse effects such as withdrawal symptoms, dependence and abuse have not previously been reported in relation to zolpidem. " 08/30/1993 - "Withdrawal symptoms and ultimately psychosis developed in two cases following cessation of the hypno-sedative zolpidem. "
5.	Sleep Disorders 07/01/2002 - "With discontinuation of zolpidem and effective treatment of their sleep disorders, nocturnal eating resolved. " 04/01/1992 - "The safety and efficacy of 10 or 20 mg/day zolpidem, a new hypnotic belonging to the imidazopyridine class, were studied over a 180-day period in 96 patients with sleep disorders. " 09/01/2015 - "Overall, patients with nonapnea sleep disorders using zolpidem had a higher risk of T2DM compared with patients not using zolpidem and the control cohort (adjusted hazard ratio [HR] = 1.41, 95% confidence interval [CI] = 1.35-1.48). " 01/01/2010 - "Zolpidem is a hypnotic drug used in sleep disorders. " 01/01/2004 - "Use of zolpidem in over 75-year-old patients with sleep disorders and comorbidities."

Related Drugs and Biologics

1.	Benzodiazepines
2.	zaleplon (Sonata)
3.	zopiclone (Zop)
4.	Triazolam (Halcion)
5.	Flunitrazepam (Rohypnol)
6.	Citalopram (Escitalopram)
7.	Nitrazepam (Serenade)
8.	GABA-A Receptors (GABA(A) Receptor)
9.	Temazepam (Nocturne)
10.	4,5,6,7- tetrahydroisoxazolo(5,4- c)pyridin- 3- ol (THIP)

Related Therapies and Procedures

1.	Continuous Positive Airway Pressure
2.	Aftercare (After-Treatment)
3.	Drug Therapy (Chemotherapy)
4.	Investigational Therapies (Experimental Therapy)
5.	Oral Administration