hemoglobin A2'

12/01/1978 - "Follow-up hematologic and family studies of presumptive beta-thalassemia gene carriers indicated that coordinate measurement of erythrocytic indices and Hb A2 values would have discriminated a subpopulation with a high incidence of beta-thalassemia trait more specifically. "
02/01/2019 - "Coinherited HBD mutation lowers Hb A2 and can cause a misidentification of a beta-thalassemia carrier."
02/01/2019 - "The Hb A2 levels in beta-thalassemia carriers with and without coinherited alpha0-thalassemia were not significantly different. "
02/01/2019 - "Identification of beta-thalassemia carrier in prenatal screening relies on the elevated Hb A2 level. "
05/01/2007 - "The proband had mild microcytosis with Hb 12.9 g/dl, Hct 35.8%, MCV 74.4 fl, MCH 26.8 pg, MCHC 36.0 g/dl, and elevated Hb A2 (5.6%), characteristics of beta-thalassemia trait. "

01/01/2014 - "In this study, 314 individuals with low hematological values, normal Hb A2 who were not affected with β-thal or iron deficiency, were investigated for the presence of α-thal mutations. "
07/01/2015 - "The first 2 families were identified because of microcytosis and hypochromia with a normal Hb A2 and Hb F but without iron deficiency. "
01/01/2015 - "Iron deficiency also does not reduce Hb A2 levels in β-thal minor patients. "
06/01/1985 - "The cause of the hypochromia in subjects with a normal Hb A2 (30% of the total population) is probably alpha thalassaemia, firstly because in those patients with an MCH of 19-24 pg the other haematological parameters are statistically the same as those with proven beta thalassaemia and, secondly, in those with an MCH of 25-27 pg iron deficiency is not common (6% of the population). "
10/01/2017 - "These results illustrate the diversity of α-thalassemia deletions in the Brazilian population and highlight the importance of molecular investigation in cases that present with microcytosis and hypochromia without iron deficiency and normal or reduced Hb A2 levels.."

09/01/2023 - "Meanwhile, we identified two homozygous Hb QS carriers, who showed mild to moderate anemia and increased Hb A2 level but negative results from a sequencing analysis for the first time. "
07/01/2022 - "His mother carried a β-thal trait (βA/βIVS-II-654) having mild anemia, with a classical electrophoresis pattern (95.1% Hb A, 4.4% Hb A2, 0.5% Hb F). "
05/01/2021 - "It was found in a heterozygous state in two patients who both presented severe anemia during pregnancy and moderate anemia before pregnancy; Hb A2 levels were slightly increased (more than 4.0%) in both patients. "
03/01/1995 - "The affected family members all present hematological findings typical for beta-thalassemic trait, with slight anemia, marked microcytosis, and increased levels of Hb A2."
03/01/1977 - "In the latter, the highest Hb A2 levels were observed in patients with the most severe anemia. "

02/01/1997 - "Efforts to increase the proportion of Hb A2 may be beneficial in sickle-cell disease."
07/01/1986 - "The sickle cell anemia patients had very high levels of Hb F and low levels of Hb A2. "
03/01/1971 - "The significance of raised Hb A2 levels in some of these cases is discussed with relation to the possible existence of Hb S/beta-Thalassaemia in the sickle cell disease patients examined."
09/01/2015 - "In sickle cell disease, the quantification of Hb A2 is important for the differential diagnosis between sickle cell anemia (Hb SS) and Hb S/β(0)-thalassemia. "
04/01/2000 - "In the sickle cell syndromes, Hb A2 measurements aid in the differential diagnosis of sickle cell anemia from sickle-beta-thalassemia. "

05/01/2020 - "In this study, Hb A2 variants and their association with α- and β-thalassemia (α- and β-thal) were analyzed. "
01/01/2014 - "Nine different δ chain variants and two δ-thalassemia (δ-thal) mutations were characterized in a study of 127 alleles in patients with either a low Hb A2 value or a split Hb A2 peak on high performance liquid chromatography (HPLC). "
11/01/2022 - "We describe the case of a Chinese woman with an elevated Hb A2 level who was assumed to carry heterozygous β-thalassemia (β-thal), but was later shown to be a double heterozygote for Hb G-Siriraj and Hb H disease. "
11/01/2022 - "During routine testing for thalassemia, we identified three individuals with Hb A2 levels of >10.0%. "
01/01/2022 - "A large proportion of subjects with borderline Hb A2 are not β-thalassemia carriers and for those with β-thalassemia, only mild β+-thalassemia mutations were detected. "