HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
temelastine
Also Known As:
SK&F 93944; SK&F-93944; SKF 93944
Networked:
6
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidinones: 71
temelastine: 6
Related Diseases
1.
Hypertrophy
01/01/1990 - "
The major toxicological effect of temelastine in the rat was a histopathological lesion of the thyroid gland characterized by agglomeration and depletion of colloid, follicular epithelial hypertrophy and reduced follicular size.
"
01/01/1990 - "
Rats treated with temelastine (SK&F 93,944), a novel histamine H1-receptor antagonist, develop thyroid lesions characterized by hypertrophy and colloid depletion.
"
06/01/1994 - "
Toxicological studies in the rat with phenobarbital and temelastine (SK&F 93944) are associated with thyroid lesions, characterized by thyroid stimulated hormone-mediated thyroid follicular cell hypertrophy and hyperplasia.
"
2.
Hyperplasia
06/01/1994 - "
Toxicological studies in the rat with phenobarbital and temelastine (SK&F 93944) are associated with thyroid lesions, characterized by thyroid stimulated hormone-mediated thyroid follicular cell hypertrophy and hyperplasia.
"
3.
Tachycardia (Tachyarrhythmias)
03/01/1986 - "
In anaesthetized guinea-pigs SK&F 93944 displaced histamine bronchoconstriction dose-response curves at doses which had negligible effects on histamine tachycardia.
"
4.
Bronchial Spasm
08/01/1986 - "
In mongrel dogs natively allergic to Ascaris suum antigen, pretreatment with aerosols of either SK&F 93944 or mepyramine (1%; 50 tidal breaths) significantly inhibited bronchospasm elicited by increasing aerosol concentrations of antigen.
"
5.
Body Weight (Weight, Body)
10/01/1989 - "
Temelastine (SK&F 93944), an H1 histamine receptor antagonist, induces thyroid histopathological lesions in the rat, indicative of thyroid follicular cell stimulation, at oral doses of 10-33 mg/kg body weight/day.
"
Related Drugs and Biologics
1.
temelastine
2.
Phenobarbital (Luminal)
3.
Hormones (Hormone)
4.
Histamine (Histamine Dihydrochloride)
5.
Colloids (Colloid)
6.
Histamine Receptors (Histamine Receptor)
7.
Pyrilamine (Mepyramine)
8.
Antigens
9.
Aerosols