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1- methyl- 4- (2'- methylphenyl)- 1,2,3,6- tetrahydropyridine

more potent dopaminergic neurotoxic compound than MPTP in mice

Also Known As:

2'-CH3-MPTP; 2'-methyl-MPTP; M-MPTP

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: 3976
      - 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine: 4

Experts

1.	Ho, Gideon: 1 article (11/2008)
2.	Kng, Yin Ling: 1 article (11/2008)
3.	Kumar, Saravana: 1 article (11/2008)
4.	Zhang, Chunyan: 1 article (11/2008)
5.	Zhuo, Lang: 1 article (11/2008)

Related Diseases

1.	Herpes Zoster 03/18/1986 - "Moreover, 2'-CH3-MPTP administration (as few as four injections) caused a virtually complete loss of nerve cells in the zona compacta of the substantia nigra. " 05/31/1990 - "Histological examination of the substantia nigra from the four animals treated with 2'-methyl-MPTP did not show degeneration or loss of dopamine-containing cell bodies in the zona compacta. "
2.	Parkinson Disease (Parkinson's Disease) 03/01/1990 - "A rodent model of Parkinson's disease, the 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine treated mouse, was used to determine whether striatal dopamine levels recover following grafting adrenal medulla into the striatum. "
3.	Gliosis 11/01/2008 - "We previously reported that a single subcutaneous (s.c.) injection of the neurotoxicant, 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine or 2'-CH(3)-MPTP, to postnatal day 4 (PD4) mice caused acute and transient gliosis in the brain, which can be noninvasively monitored during a course of 8 h immediately after the dosing [Ho, G., Zhang, C.Y., Zhuo, L., 2007. "

Related Drugs and Biologics

1.	Dopamine (Intropin)

Related Therapies and Procedures

1.	Injections