NPK 1886

RN given from Toxline; RN not in Chemline 6/86

Also Known As:

NB 818; NB-818; NPK-1886; isopropyl methyl 2-carbamoyloxymethyl-6-methyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Dihydropyridines: 214
      - NPK 1886: 4

Related Diseases

1.	Hypotension (Low Blood Pressure) 01/01/1988 - "5) NB-818 0.003-0.1 mg/kg intraduodenally (i.d.) also caused a longer lasting increase in VBF with a slower onset that was accompanied by moderate hypotension and was dose-dependent. " 01/01/1988 - "The results from the present study indicate that NB-818 predominantly increases rCBF with a concomitant moderate hypotension, and its action is greater than that of nicardipine or nimodipine." 01/01/1988 - "Thus, NB-818 predominantly increases VBF with concomitant moderate hypotension, and its action is of significantly slower onset and longer duration than that of nicardipine and nimodipine."
2.	Ischemia 07/01/1991 - "In this experiment, NB-818 exhibited a protective effect on DND in the hippocampal CA1 subfield after transient forebrain ischemia, and its effect persisted for up to 4 weeks. " 07/01/1991 - "In addition, NB-818 (3 mg/kg) significantly inhibited DND at 1, 2 and 4 weeks after transient ischemia: the average NCD of the NB-818 and ischemic control groups were 80 +/- 9.4 (P less than 0.01) and 43 +/- 7.7 cells/mm, 92 +/- 13.7 (P less than 0.05) and 52 +/- 9.3 cells/mm, and 57 +/- 5.0 (P less than 0.01) and 43 +/- 12.4 cells/mm, respectively. " 07/01/1991 - "The effect of NB-818, a new dihydropyridine calcium entry blocker, on delayed neuronal death (DND) in the hippocampal CA1 subfield of gerbils after 5 minutes of forebrain ischemia induced by bilateral carotid artery occlusion was examined. "
3.	Brain Edema (Cerebral Edema) 08/01/1988 - "The brain edema was significantly inhibited by NB-818 in the type II but not in the type III because the increased rCBF in type III with NB-818 was slight.(ABSTRACT TRUNCATED AT 250 WORDS)"

Related Drugs and Biologics

1.	Nimodipine (Modus)
2.	Nicardipine (Dagan)
3.	Calcium
4.	1,4-dihydropyridine (dihydropyridine)