HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

indo-1

structure given in first source
Also Known As:
indo 1; 1H-Indole-6-carboxylic acid, 2-(4-(bis(carboxymethyl)amino)-3-(2-(2-(bis(carboxymethyl)amino)-5-methylphenoxy)ethoxy)phenyl)-
Networked: 91 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Buckler, Keith J: 3 articles (11/2020 - 01/2010)
2. Pandit, Jaideep J: 3 articles (11/2020 - 01/2010)
3. Westerblad, Håkan: 3 articles (12/2017 - 06/2002)
4. Ivarsson, Niklas: 2 articles (12/2017 - 11/2010)
5. Bruton, Joseph D: 2 articles (11/2010 - 10/2003)
6. Katz, Abram: 2 articles (11/2010 - 06/2002)
7. Buckler, K J: 2 articles (11/2009 - 07/2000)
8. MacLeod, K T: 2 articles (03/2006 - 02/2001)
9. Naqvi, R U: 2 articles (03/2006 - 02/2001)
10. Huskens, Nicky: 1 article (11/2020)

Related Diseases

1. Fatigue
11/01/2010 - "[Ca2+]i (measured with indo-1) and force were measured under control conditions and during fatigue induced by repeated tetanic stimulation in intact single fibres. "
06/01/2002 - "During the first fatigue run, the fluorescence ratio for indo 1 increased [reflecting an increase in myoplasmic free Ca2+ concentration ([Ca2+]i)] during the initial tetani, peaking at approximately 115% of the first tetanic value, followed by a continuous decrease to approximately 90% at fatigue. "
12/15/2017 - "Recovery of submaximal force (30 Hz), the tetanic myoplasmic free [Ca2+ ] (measured with the fluorescent indicator indo-1), and fatigue resistance were all impaired by cooling (16-26°C) and improved by heating (36°C). "
10/15/2003 - "The rapid force decline in CK-/- fibres was not due to decreased myoplasmic [Ca2+] during tetani (measured with indo-1), which in these fibres remained virtually constant during fatigue in the presence of cyanide. "
03/01/1993 - "Intracellular calcium signals were monitored using the fluorescent calcium-sensitive indicator indo-1 from the ratio of fluorescence intensities (R) at 400 and 470 nm. Fatiguing stimulation caused 1) proportional decreases of tetanic force and R, suggesting a component of the decreased force during fatigue of whole muscle may be due to insufficient calcium to activate contraction; 2) a progressive slowing of the relaxation of both force and R, suggesting slowed force relaxation may be mediated by slowed calcium removal from the myoplasm; 3) an increase of resting level R, suggesting impaired calcium removal from, or increased leakage to the cytosol; 4) prolongation of the twitch contraction, which was paralleled by changes in R. "
2. Contracture
3. Acidosis
4. Hypoxia (Hypoxemia)
5. Coronary Thrombosis

Related Drugs and Biologics

1. Indicators and Reagents (Reagents)
2. Calcium
3. Halothane (Fluothane)
4. Coloring Agents (Dyes)
5. Caffeine (No Doz)
6. Proteins (Proteins, Gene)
7. Sevoflurane (Ultane)
8. Fura-2 (Fura 2)
9. Fluorescent Dyes (Fluorescent Probes)
10. Suspensions

Related Therapies and Procedures

1. Lasers (Laser)
2. Gas Lasers
3. Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
4. Heart Transplantation (Grafting, Heart)
5. Therapeutics