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Disperse Blue 1
Also Known As:
1,4,5,8-tetraaminoanthracene-9,10-dione; C.I. Disperse Blue 1; Oracet blue; 9,10-Anthracenedione, 1,4,5,8-tetraamino-
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Anthracenes: 12
Anthrones: 12
Anthraquinones: 788
Disperse Blue 1: 2
Quinones: 434
Anthraquinones: 788
Disperse Blue 1: 2
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Anthracenes: 12
Anthrones: 12
Anthraquinones: 788
Disperse Blue 1: 2
Related Diseases
1.
Carcinogenesis
05/01/1986 - "
An audit of the experimental data was conducted for the 2-year toxicology and carcinogenesis studies of C.I. Disperse Blue 1. No data discrepancies were found that influenced the final interpretations.
"
05/01/1986 - "
NTP Toxicology and Carcinogenesis Studies of C.I. Disperse Blue 1 (A commercial dye containing approximately 50% 1,4,5,8-tetraaminoanthraquinone, and 20% water) (CAS No. 2475-45-8) in F344/N Rats and B6C3F1 Mice (Feed Studies).
"
02/01/1994 - "
Dietary administration of Disperse Blue 1 in a National Toxicology Program (NTP) carcinogenesis bioassay produced transitional- and squamous-cell tumors, leiomyomas, and leiomyosarcomas of the urinary bladders of male and female F344/N rats.
"
2.
Leiomyosarcoma
05/01/1986 - "
Under the conditions of these feed studies of C.I. Disperse Blue 1, there was clear evidence of carcinogenicity for male and female F344/N rats as shown by the increased occurrence of transitional cell papillomas and carcinomas, of leiomyomas and leiomyosarcomas, and of squamous cell papillomas and carcinomas of the urinary bladder.
"
02/01/1994 - "
Dietary administration of Disperse Blue 1 in a National Toxicology Program (NTP) carcinogenesis bioassay produced transitional- and squamous-cell tumors, leiomyomas, and leiomyosarcomas of the urinary bladders of male and female F344/N rats.
"
3.
Leiomyoma (Uterine Fibroids)
05/01/1986 - "
Under the conditions of these feed studies of C.I. Disperse Blue 1, there was clear evidence of carcinogenicity for male and female F344/N rats as shown by the increased occurrence of transitional cell papillomas and carcinomas, of leiomyomas and leiomyosarcomas, and of squamous cell papillomas and carcinomas of the urinary bladder.
"
02/01/1994 - "
Dietary administration of Disperse Blue 1 in a National Toxicology Program (NTP) carcinogenesis bioassay produced transitional- and squamous-cell tumors, leiomyomas, and leiomyosarcomas of the urinary bladders of male and female F344/N rats.
"
4.
Papilloma (Papillomatosis)
05/01/1986 - "
Under the conditions of these feed studies of C.I. Disperse Blue 1, there was clear evidence of carcinogenicity for male and female F344/N rats as shown by the increased occurrence of transitional cell papillomas and carcinomas, of leiomyomas and leiomyosarcomas, and of squamous cell papillomas and carcinomas of the urinary bladder.
"
5.
Carcinoma (Carcinomatosis)
05/01/1986 - "
A marginally increased occurrence of pancreatic islet cell adenomas or carcinomas (combined) was observed in male rats exposed to C.I. Disperse Blue 1. There was equivocal evidence of carcinogenicity of C.I. Disperse Blue 1 in male B6C3F1 mice as shown by marginally increased incidences of hepatocellular adenomas or carcinomas (combined) in dosed male mice and a marginally increased occurrence of alveolar/bronchiolar adenomas or carcinomas (combined) in high dose male mice.
"
05/01/1986 - "
Under the conditions of these feed studies of C.I. Disperse Blue 1, there was clear evidence of carcinogenicity for male and female F344/N rats as shown by the increased occurrence of transitional cell papillomas and carcinomas, of leiomyomas and leiomyosarcomas, and of squamous cell papillomas and carcinomas of the urinary bladder.
"
Related Drugs and Biologics
1.
Coloring Agents (Dyes)