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zincov

RN given refers to (L)-isomer

Also Known As:

2-(N-hydroxycarboxamido)-4-methylpentanoyl-alanyl-glycinamide; HC-MP-Ala-GlyNH2

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Hydroxamic Acids: 239
      - zincov: 3
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxamic Acids: 239
      - zincov: 3

Experts

1.	Slomiany, A: 1 article (12/2000)
2.	Slomiany, B L: 1 article (12/2000)

Related Diseases

1.	Ulcer 12/01/2000 - "Treatment with metalloprotease inhibitor, Zincov, produced dose-dependent reduction (56.9%) in aspirin-induced increase in the mucosal expression of soluble TNF-alpha, evoked a 62% decrease in the rate of epithelial cell apoptosis, and led to a marked reversal (56.9%) in aspirin-induced delay in ulcer healing. "
2.	Shock 02/01/1995 - "This shock was prevented either with a specific elastase inhibitor, HONHCOCH(CH2C6H5)CO-Ala-Gly-NH2, zincov (6 microM), or with human alpha 2M. "
3.	Cholera 06/22/1987 - "Inhibition of the filtrate metalloproteinase by Zincov and alpha 2-macroglobulin significantly (P less than 0.005) reduced the ability of cholera filtrate to degrade mucin or to stimulate mucin secretion from rat intestinal slices in vitro. "

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Pancreatic Elastase (Elastase)
5.	Mucins
6.	Aspirin (Acetylsalicylic Acid)