tetranectin

MW 68,000; consists of 4 subunits each with MW 17,000; interacts specifically with the kringle 4 part of plasminogen; RefSeq NM_003278 (human); NM_011606 (mouse)

Also Known As:

C-type lectin domain family 3, member B protein, human; C-type lectin domain family 3, member b protein, mouse; CLEC3B protein, human; Clec3b protein, mouse; plasminogen kringle 4-binding protein, human; tetranectin protein, human; tetranectin protein, mouse

Networked: 83 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Lectins: 6782
    - C-Type Lectins: 976
      - tetranectin: 83

Experts

1.	Blaakaer, Jan: 5 articles (05/2015 - 05/2004)
2.	Christensen, Lise: 5 articles (05/2015 - 05/2004)
3.	Høgdall, Claus K: 5 articles (05/2015 - 05/2002)
4.	Høgdall, Estrid V S: 3 articles (05/2015 - 05/2004)
5.	Kjaer, Susanne K: 3 articles (05/2015 - 05/2004)
6.	Begum, Farah Diba: 3 articles (06/2010 - 05/2004)
7.	Christiansen, M: 3 articles (06/2007 - 04/2004)
8.	Ensinger, C: 3 articles (06/2007 - 04/2004)
9.	Høgdall, C K: 3 articles (01/2006 - 09/2000)
10.	Iba, Kousuke: 2 articles (01/2022 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 11/01/1991 - "A significant reduction of plasma tetranectin was found in every malignant tumor type except for mucinous tumors. " 05/01/2009 - "These aims were addressed in the present study by evaluating serum tetranectin (TN) and serum CA125 on a large number of pre- and postmenopausal women with ovarian tumors and controls. " 10/17/1994 - "Tetranectin may be a new prognostic marker which should be included in future clinical studies evaluating the prognosis for cancer patients." 01/01/2017 - "In malignancies, tetranectin is thought to enhance proteolytic processes enabling tumor cells to invade and metastasize. " 05/01/2009 - "Preoperative serum tetranectin, CA125 and menopausal status used as single markers in screening and in a risk assessment index (RAI) in discriminating between benign and malignant ovarian tumors."
2.	Ovarian Epithelial Carcinoma 03/01/1995 - "In a previous study, we have demonstrated that inhibin-production may be associated with improved survival and, also, that tetranectin (TN) is a valuable prognostic marker in ovarian epithelial cancer. "
3.	Ovarian Neoplasms (Ovarian Cancer) 05/01/2002 - "To study the prognostic value of pre-operative serum tetranectin (TN), CA125 levels and a mathematical formula (Index1) in primary ovarian cancer. " 12/01/2000 - "The aim of the study was to examine the prognostic values of, respectively, tetranectin (TN) and CA-125 measured in serum from patients presenting with relapse of ovarian cancer (OC). " 05/01/2015 - "Tetranectin positive expression in tumour tissue leads to longer survival in Danish women with ovarian cancer. " 01/01/2010 - "To evaluate the prognostic value of preoperative serum tetranectin (TN) in Danish ovarian cancer (OvCa) patients. " 01/01/2010 - "Serum tetranectin is a significant prognostic marker in ovarian cancer patients."
4.	Carcinoma (Carcinomatosis) 01/01/2002 - "Overall, the mucinous signet ring carcinomas showed significantly higher tetranectin expression compared to ITA (chi2 = 3.95, p<0.05). " 01/01/2002 - "Of the ten cases of mucinous signet ring cell carcinomas 5 showed high, 3 moderate and 2 low tetranectin expression. " 10/17/1994 - "Lifetables of patients with ovarian carcinoma show that high concentrations of extracellular tetranectin is associated with a poor prognosis. " 10/17/1994 - "While tetranectin is absent in normal extracellular matrix, it is found extracellulary in granulation tissues and in some carcinomas of the breast and the ovary. " 11/01/1994 - "Within the tissue homogenates no differences were found in the tetranectin levels between normal mucosa, adenomas and carcinomas. "
5.	Breast Neoplasms (Breast Cancer) 04/01/2004 - "Aberrant tetranectin expression in human breast carcinomas as a predictor of survival." 01/01/1993 - "Prognostic value of serum tetranectin in patients with metastatic breast cancer." 01/01/1993 - "To evaluate serum tetranectin as a prognostic marker before first-line chemotherapy, serum levels were studied in 67 patients with metastatic breast cancer. " 10/17/1994 - "The degree of tetranectin reduction in the blood from patients with ovarian carcinoma and metastasizing breast carcinoma correlates with survival. " 03/16/2023 - "Furthermore, diosgenin was observed to exert a pronounced anti-proliferative effect on high tetranectin-expressing MDA-MB-231 breast cancer cells. "

Related Drugs and Biologics

1.	Inhibins (Inhibin)
2.	Laminin (Merosin)
3.	Proteins (Proteins, Gene)
4.	Biomarkers (Surrogate Marker)
5.	Plasminogen Activator Inhibitor 1
6.	Messenger RNA (mRNA)
7.	Fibronectins (Fibronectin)
8.	Plasminogen Activator Inhibitor 2
9.	Plasminogen Inactivators
10.	Interleukins

Related Therapies and Procedures

1.	Osteotomy
2.	Gastrectomy
3.	Drug Therapy (Chemotherapy)
4.	Cytoreduction Surgical Procedures
5.	Ovariectomy (Oophorectomy)