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fibrinogen Milano II

defective interaction with thrombin is associated with a defective binding of thrombin to the fibrin moiety of Milano II

Also Known As:

fibrinogen Naples

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Blood Coagulation Factors: 5376
      - Fibrinogen: 15409
        Abnormal Fibrinogens: 8
        fibrinogen Milano II: 4
    - Acute-Phase Proteins: 5159
      - Fibrinogen: 15409
        Abnormal Fibrinogens: 8
        fibrinogen Milano II: 4
Biological Factors: 2472
- Blood Coagulation Factors: 5376
  - Fibrinogen: 15409
    - Abnormal Fibrinogens: 8
      - fibrinogen Milano II: 4

Experts

1.	Amano, Koji: 1 article (10/2017)
2.	Kibe, Tetsuya: 1 article (10/2017)
3.	Koizumi, Shin-Ichiro: 1 article (10/2017)
4.	Matsubara, Risa: 1 article (10/2017)
5.	Nara, Kenji: 1 article (10/2017)
6.	Okumura, Nobuo: 1 article (10/2017)
7.	Yoshida, Satoru: 1 article (10/2017)
8.	Mosesson, Michael W: 1 article (07/2007)

Related Diseases

1.	Thrombosis (Thrombus) 10/01/2017 - "Congenital dysfibrinogenemia in a Japanese family with fibrinogen Naples (BβAla68Thr) manifesting as superior sagittal sinus thrombosis." 07/01/2007 - "fibrinogen Naples 1), or a reduced plasma gamma' chain content (reduced antithrombin I activity), predispose to intravascular thrombosis."
2.	Venous Thrombosis (Deep-Vein Thrombosis) 02/28/1986 - "Fibrinogen Milano II: a congenital dysfibrinogenaemia associated with juvenile arterial and venous thrombosis."
3.	Thrombophilia 07/01/1992 - "Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. " 07/01/1992 - "In an abnormal fibrinogen (fibrinogen Naples) associated with congenital thrombophilia we have identified a single base substitution (G----A) in the B beta chain gene that results in an amino acid substitution of alanine by threonine at position 68 in the B beta chain of fibrinogen. "
4.	Congenital Dysfibrinogenemia 10/01/2017 - "Congenital dysfibrinogenemia in a Japanese family with fibrinogen Naples (BβAla68Thr) manifesting as superior sagittal sinus thrombosis."

Related Drugs and Biologics

1.	Thrombin
2.	Threonine (L-Threonine)
3.	Fibrinogen (Factor I)
4.	Fibrin
5.	Alanine (L-Alanine)