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hexahydroazepine

RN given refers to parent cpd

Also Known As:

hexahydroazepine hydrochloride; perhydroazepine

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - hexahydroazepine: 3

Experts

1.	Campos, Joaquín M: 1 article (04/2012)
2.	Gómez-Pérez, Verónica: 1 article (04/2012)
3.	Konrad, Manfred: 1 article (04/2012)
4.	McSorley, Theresa: 1 article (04/2012)
5.	See Too, Wei Cun: 1 article (04/2012)

Related Diseases

1.	Pain (Aches) 01/01/1976 - "The pain relieving properties of orally administered meptazinol, a new hexahydroazepine analgesic, were studied in 51 patients recovering from major surgery. " 11/01/1977 - "In a double-blind investigation of the efficacy on pain following abdominal or orthopaedic surgery, meptazinol 100 mg, a new hexahydroazepine derivative, was found to be equipotent with pentazocine 60 mg and pethidine 100 mg when given i.m. "
2.	Breast Neoplasms (Breast Cancer) 04/01/2012 - "1,1'-[(Butane-1,3-diylbis(benzene-1,4-diylmethylene)]bis[4-(4-bromo-N-methylanilino)pyridinium)] dibromide and 1,1'-(biphenyl-3,3'-diylmethylene)bis[7-chloro-4-(perhydroazepine-1-yl)quinolinium] dibromide were identified as highly potent ChoK inhibitors with IC(50) values of 80 nM. Kinetic enzymatic assays indicated a mixed and predominantly competitive mechanism of inhibition for these compounds, which exhibited strong antiproliferative activity (EC(50) 1 μM) against the human breast cancer SKBR3 cell line."

Related Drugs and Biologics

1.	Meptazinol
2.	Pentazocine (Talwin)
3.	Meperidine (Pethidine)
4.	Benzene (Benzole)
5.	Analgesics (Analgesic Drugs)
6.	butane
7.	quinolinium dibromide (QdB)
8.	diphenyl (biphenyl)