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ONO 6240

Also Known As:

1-O-hexadecyl-O-ethyl-3-O-(7-thiazo-lipoheptyl)glyceryl-methanesulfonate; ONO-6240; Thiazolium, 3-(7-(2-ethoxy-3-(hexadecyloxy)propoxy)heptyl)-, (+-)-, methanesulfonate

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - ONO 6240: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - ONO 6240: 5

Related Diseases

1.	Hypotension (Low Blood Pressure) 04/09/1986 - "We found that SRI 63-072 (3 mg/kg), SRI 63-119 (3 mg/kg) and ONO-6240 (2 mg/kg) significantly improved the initial hypotension, hemoconcentration and leukopenia caused by PAF. " 12/01/1991 - "CV-3988 and ONO-6240, selective PAF antagonists, prevented hypotension and death caused by the administration of WNM or PAF. "
2.	Leukopenia 04/09/1986 - "We found that SRI 63-072 (3 mg/kg), SRI 63-119 (3 mg/kg) and ONO-6240 (2 mg/kg) significantly improved the initial hypotension, hemoconcentration and leukopenia caused by PAF. "
3.	Pulmonary Hypertension 02/01/1986 - "However, pretreatment with ONO-6240 had little effect on pulmonary hypertension and lung lymph balance. " 01/01/1990 - "It has been reported that a platelet-activating factor (PAF) antagonist ONO-6240 had little effect on pulmonary hypertension and lung lymph in sheep injected with endotoxin lipopolysaccharide (LPS); consequently we evaluated a new PAF antagonist, BN 52021. "
4.	Septic Shock (Toxic Shock Syndrome) 02/01/1986 - "To determine the role of platelet-activating factor (PAF) in endotoxin shock, we studied the effects of ONO-6240, a PAF antagonist, on endotoxin shock in unanesthetized sheep. " 02/01/1986 - "Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep."
5.	Necrosis 04/09/1986 - "(R,S)-3-[2-[(2-octadecylaminocarbonyloxymethyltetrahydro-2-fura nylmethoxy) -hydroxyphosphinyloxy]-ethyl]-thiazolium hydroxide inner salt 4-oxide (SRI 63-072), (+/-)-3-[4-[3-octadecylaminocarbonyloxy-2-methoxy)-propoxy]-butyl] -thiazolium bromide (SRI 63-119) and 1-O-hexadecyl-2RS-O-ethyl-3-O -(7-thiazolinoheptyl)-glycerol-methanesulfonate (ONO-6240), on PAF-induced bowel necrosis. "

Related Drugs and Biologics

1.	Platelet Activating Factor
2.	Interleukin-5 (Interleukin 5)
3.	Salts
4.	Lipopolysaccharides
5.	Interleukin-2 (IL2)
6.	Glycerol (Glycerine)
7.	Endotoxins
8.	Bromides
9.	methanesulfonic acid (methanesulfonate)
10.	ginkgolide B