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nimbic acid
isolated from the leaves of Azadirachta indica var. Siamensis; structure given in first source
Also Known As:
18,24-Dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic acid, 7,15:21,23-diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-, 11-methyl ester, (4alpha,5alpha,6alpha,7alpha,15beta,17alpha)-
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Terpenes: 1461
Triterpenes: 2493
nimbic acid: 2
Related Diseases
1.
Shock
02/01/1986 - "
LD50 values of higher than 600 mg/kg body wt. The possible cause of death induced by nimbic acid may be similar to that of nimbolide given i.v. and this is a sudden hypotensive shock.
"
2.
Osteosarcoma (Osteogenic Sarcoma)
09/01/2023 - "
The numerous therapeutic properties of natural substances in traditional medicine compel us to investigate the anti-cancer properties of Nimbin (N1) and its semi-natural analog Nimbic acid (N3) from Azadirachta indica against MG-63 Osteosarcoma cells.
"
3.
Respiratory Paralysis
02/01/1986 - "
In contrast, mice and rats given a lethal dose of nimbolide (i.v.) died of a marked and sudden drop in arterial blood pressure and respiratory paralysis within about 1-18 min. Nimbic acid was less toxic to mice with an i.v. LD50 value of 265 mg/kg body wt and i.p.
"
4.
Neoplasms (Cancer)
09/01/2023 - "
The numerous therapeutic properties of natural substances in traditional medicine compel us to investigate the anti-cancer properties of Nimbin (N1) and its semi-natural analog Nimbic acid (N3) from Azadirachta indica against MG-63 Osteosarcoma cells.
"
Related Drugs and Biologics
1.
nimbolide
2.
nimbin
Related Therapies and Procedures
1.
Traditional Medicine (Folk Remedies)