paxilline

09/24/2022 - "A number of in vitro, in vivo, ex vivo and in silico studies have confirmed that luteolin activates this channel in the mitochondria of cardiomyocytes and endothelial cells, which in turn leads to the protection of the endothelium and a significant reduction in the extent of damage resulting from myocardial infarction, where this effect was partially abolished by the mitoBKCa channel blocker paxilline. "

11/01/2010 - "Paxilline itself had no effect on infarct size (NS vs control). "
08/01/2010 - "Infarct size reduction was abolished by paxilline (MPC + Pax: 37 +/- 7%, P < 0.05 vs MPC and IPC + Pax: 36 +/- 6%, P < 0.05 vs IPC), whereas paxilline alone had no effect (Pax: 46 +/- 7%, not significantly different from Control). "
10/01/2018 - "Paxilline completely blocked milrinone-induced cardioprotection whereas paxilline alone had no effect on infarct size. "
10/01/2018 - "Paxilline completely blocked levosimendan-induced cardioprotection while paxilline alone had no effect on infarct size. "
01/01/2008 - "Treatment with sildenafil reduced infarct size, which was abolished by either paxilline or 5-HD. "

08/01/2021 - "To explore this concept, we used the BKCa channel antagonist paxilline to evaluate the role of BKCa channel function in phenotypes of neurodevelopmental disorders. "
08/01/2021 - "Future studies which examine the effective dose range of paxilline and exhaustive assays of behavior relevant to neurodevelopmental disorders will be needed to delineate the parametric space of the paxilline effect, particularly during critical periods of development, and its potential for therapeutic use. "

03/31/2020 - "In this study, we tested 24 commercially available seed mixtures for their infection rates with Epichloë endophytes and measured the concentrations of the alkaloids ergovaline, lolitrem B, paxilline, and peramine. "

01/01/2019 - "The mitoBKCa blocker paxilline (PAX) (1ml/kg, 115 nM) was administered via tail vein injection 30min prior to the onset of ischemia. "
01/01/2015 - "The mBKCa channel inhibitor paxilline (1 μM) was administered with and without sildenafil before the onset of ischemia. "
11/01/2007 - "Hearts from normoxic or hypoxic infant rabbits were perfused with a mitoKCa opener, NS1619, or blocker Paxilline before ischemia and reperfusion. "
02/01/2005 - "In the isolated perfused rat heart subjected to ischemia/reperfusion, effects of ischemic preconditioning (IPC) on infarct size and lactate dehydrogenase (LDH) release were abolished by 1 microM paxilline (Pax), an inhibitor of the K(Ca) channel, administered 30 min before, but not during, ischemia. "
12/07/2005 - "Pretreatment with 0.2 micromol/L cyclosporin A for the last 5 min of ischemia and first 15 min of reperfusion showed similar effects to those of TNF-alpha, and they were not attenuated by paxilline. "