panomifene

structure given in UD 36:24m

Also Known As:

1,2-diphenyl-1(4-((2-hydroxyethylamino)ethoxy)phenyl)-3,3,3-trifluoro-1-propene; EGIS 5650; EGIS-5650; GYKI 13504; GYKI-13504; Ethanol, 2-((2-(4-(3,3,3-trifluoro-1,2-diphenyl-1-propenyl)phenoxy)ethyl)amino)-, (E)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        Stilbenes: 657
        Tamoxifen: 14288
        panomifene: 2

Related Diseases

1.	Neoplasms (Cancer) 12/01/1997 - "In vitro metabolism of panomifene (E-1,2-diphenyl-1--4-(2-(2-hydroxyethyl-amino)-ethoxy)-phenyl--3,3,3- trifluoropropene), a novel antiestrogen against hormone dependent tumors, has been investigated using liver microsomes from mouse, rat, dog, and human. " 01/01/1996 - "Out of the triphenyl-alkene derivatives Panomifene (EGIS-5660) proved to be the most active antiestrogenic compound which binds to specific estrogen receptors and exhibits inhibitory effects on experimental mammary tumors both in vitro and in vivo. "
2.	Breast Neoplasms (Breast Cancer) 12/01/1997 - "The structure of panomifene is analogous to tamoxifen, an antiestrogen currently used as a therapeutic agent against breast cancer, and there are some similar routes in their metabolism. "

Related Drugs and Biologics

1.	Estrogen Receptor Modulators (Antiestrogen)
2.	Tamoxifen
3.	Estrogen Receptors
4.	Hormones (Hormone)
5.	Alkenes (Olefins)