prolame

a derivative of natural estrogenic steroid with a 17-beta-amino-alcohol side chain, 3-hydroxypropylamine; exhibits estrogenic and anti-coagulation effects

Also Known As:

17beta-(3-hydroxy-1-propylamino)-1,3,5(10)-estratrien-3-ol; N-(3-hydroxy-1,3,5(10)-estratrien-17-yl)-3-hydroxypropylamine; Estra-1,3,5(10)-trien-3-ol, 17-((3-hydroxypropyl)amino)-, (17beta)-

Networked: 9 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Estranes
      - Estrenes
        prolame: 9

Experts

1.	Fernández-G, Juan Manuel: 2 articles (10/2017 - 01/2010)
2.	Guevara, Jorge: 2 articles (10/2017 - 06/2012)
3.	Montaño, Luis F: 2 articles (10/2017 - 06/2012)
4.	de la Peña, Aurora: 2 articles (03/2015 - 01/2010)
5.	Diaz, Alfonso: 1 article (10/2017)
6.	Espinosa, Blanca: 1 article (10/2017)
7.	Flores, Gonzalo: 1 article (10/2017)
8.	Treviño, Samuel: 1 article (10/2017)
9.	Venegas, Berenice: 1 article (10/2017)
10.	Vázquez-Roque, Rubén: 1 article (10/2017)

Related Diseases

1.	Thrombosis (Thrombus) 01/01/2010 - "(d) Prolame reduces the formation of thrombi in an in vivo thrombosis model. " 01/01/2010 - "We also studied the impact of prolame-treated endothelial cells (EC) on ADP-induced platelet aggregation, as well as the ability to prevent occlusive thrombi in an in vivo mice thrombosis model. " 02/01/1985 - "The evidence suggests that, in contrast with currently used estrogens, prolame would not generate cardiovascular accidents if used for the treatment of prostatic carcinoma; it could also be exceptionally effective for the prevention of thrombosis."
2.	Carcinoma (Carcinomatosis) 02/01/1985 - "The evidence suggests that, in contrast with currently used estrogens, prolame would not generate cardiovascular accidents if used for the treatment of prostatic carcinoma; it could also be exceptionally effective for the prevention of thrombosis."
3.	Gliosis 06/15/2012 - "In our study we evaluated the role of prolame on Aβ(25-35)-caused oxidative stress, reactive astrogliosis, and impairment of spatial memory(.) The Aβ(25-35) (100 μM/μl) or vehicle was injected into the CA1 subfield of the hippocampus of the rat. " 06/15/2012 - "The prolame treatment significantly reduced spatial-memory impairment and decreased lipid peroxidation, reactive oxygen species, and reactive gliosis. "
4.	Lordosis 01/01/2009 - "This work evaluates the influence of single and multiple administration of a homologous series of the AEs: prolame, butolame and pentolame on rat female sexual behavior to explore their capability of inducing lordosis by themselves. " 03/23/2009 - "Dose-response curves were performed in rats by single subcutaneous (s.c.) injection (timezero) of: E2 (approximately 0.3, 3, 30, 60, 300 microg/kg); EB (approximately 0.4, 4, 40, 80, 400 microg/kg); prolame, butolame, pentolame (approximately 40, 400, 2000 or 4000 mg/kg), vehicle (corn oil; 300 microL/day; approximately 1.2 mL/kg) as control; 24 h after, P (1 mg/rat in 100 microL of corn oil; approximately 4 to 5 mg/kg) was administered, and 5 to 7 h later LQ was evaluated (number of lordosis displays/number of mounts x 100). "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 10/01/2017 - "Prolame could become a pharmacological alternative to prevent or delay the brain aging process, and thus the emergence of neurodegenerative diseases that affect memory."

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	pentolame
3.	butolame
4.	NG-Nitroarginine Methyl Ester (L-NAME)
5.	Nitric Oxide Synthase (NO Synthase)
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Corn Oil (Oil, Corn)
8.	Adenosine Diphosphate (ADP)
9.	hexolame