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cimaterol
Also Known As:
5-(1-hydroxy-2-(isopropylamino)ethyl)anthranilonitrile; CL 263,780; CL-263,780; cimatrol; Benzonitrile, 2-amino-5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-
Networked:
23
relevant articles (
3
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Ethanolamines: 16
cimaterol: 23
Alcohols: 595
Ethanol: 23169
Ethanolamines: 16
cimaterol: 23
Amino Alcohols: 20
Ethanolamines: 16
cimaterol: 23
Related Diseases
1.
Weight Gain
11/01/1987 - "
Ten crossbred (Suffolk X Rambouillet) whether lambs were randomly assigned to receive 0 or 10 ppm cimaterol (CIM) in a completely mixed high-concentrate diet for 8 wk. Total weight gain and feed efficiency were improved 29% (P less than .05) and 14%, respectively, in the CIM-fed group.
"
01/01/1992 - "
Enhanced weight gain in skeletal muscles also occurred up to 14 d of cimaterol treatment.
"
09/01/1991 - "
Cimaterol significantly increased longissimus dorsi (P less than 0.05) and vastus lateralis (P less than 0.01) muscle weights but had no effect on semitendinosus muscle weight or live-weight gain.
"
09/01/1990 - "
Neither genotype nor cimaterol supplementation had any effect (P greater than .05) on average daily weight gain or gain-to-feed ratio.
"
12/01/1989 - "
Twelve New Zealand White rabbits were assigned to either control diets or to diets containing cimaterol for 35 d, after which they were killed and effects on performance and tissue weight gains were determined.
"
2.
Hypertrophy
01/01/1993 - "
Increased Longissimus dorsi area and hindleg width revealed muscle hypertrophy in cimaterol-treated bulls.
"
04/01/1990 - "
Cimaterol caused muscle hypertrophy and increased urinary NMH excretion.
"
10/01/1988 - "
These results suggest that cimaterol-induced muscle hypertrophy may be attained in part by reduction of myofibrillar protein degradation.
"
12/01/1987 - "
Cimaterol-induced muscle hypertrophy and altered endocrine status in lambs.
"
10/01/1988 - "
The purpose of this study was to reveal the possible relationships between total Ca2+-dependent proteinase (CDP) and micromolar-Ca2+-dependent proteinase (microM CDP) activity and cimaterol-induced hypertrophy of skeletal muscle.
"
3.
Body Weight (Weight, Body)
10/01/1991 - "
Twelve Friesian steers (liveweight = 488 +/- 3 kg) were randomly assigned to receive either 0 (control; n = 6) or .09 mg cimaterol/kg body weight/day (treated; n = 6).
"
01/01/1989 - "
Cimaterol administration resulted in a greater reduction in body weight gain in the Large strain rats.
"
02/01/1988 - "
Epididymal fat as a percentage of empty body weight decreased at a faster rate in M16 than in ICR as cimaterol level increased.
"
05/01/1987 - "
Pigs were fed cimaterol (at 0, .25 and .50 mg X kg-1 diet) and either an adequate (18%) or restricted (14%) protein diet from about 10 to 60 kg body weight.
"
4.
Sarcoma (Soft Tissue Sarcoma)
09/01/1995 - "
To determine the influence of cimaterol on protein synthesis, a methylcholanthrene sarcoma was transplanted sc into the dorsum of male Fischer-344 rats.
"
01/01/1993 - "
To determine the most efficacious dose of the beta 2-agonist cimaterol (CIM), male Fischer-344 rats with dorsal subcutaneous methylcholanthrene sarcomas were maintained on supplemental enteral nutrition via surgically placed gastrostomy tubes.
"
10/01/1991 - "
Cimaterol was administered to tumor-bearing rats receiving total parenteral nutrition or enteral nutrition for 10 days, beginning 2 weeks after subcutaneous transplantation of methylcholanthrene sarcoma.
"
5.
Neoplasms (Cancer)
09/01/1995 - "
Anticatabolic effect of the beta 2-agonist cimaterol in vivo in tumor-bearing animals.
"
09/01/1995 - "
After 3 weeks of tumor growth, tumor-bearing and control animals received daily sc injections of the beta 2-agonist cimaterol (0.15 mg/kg) for 5 days.
"
10/01/1991 - "
Reversal of cancer cachexia in rats by cimaterol and supplemental nutrition.
"
09/01/1995 - "
There was a significant increase in protein synthesis rate in control and tumor-bearing animals receiving cimaterol compared to that in freely feeding, food-deprived, or matched-carcass-weight nontumor-bearing controls, as well as compared to that in tumor-bearing controls.
"
09/01/1995 - "
The beta 2-agonist cimaterol increases muscle mass and protein content in tumor-bearing animals, in part by decreasing protein degradation, but the effect of the drug on protein synthesis remains uncertain.
"
Related Drugs and Biologics
1.
Proteins (Proteins, Gene)
2.
Adrenergic beta-Agonists (beta-Adrenergic Agonists)
3.
Nucleic Acids
4.
Dihydrotachysterol (AT 10)
5.
Peptide Hydrolases (Proteases)
6.
Cytidine Diphosphate (CDP)
7.
Methylcholanthrene
8.
Muscle Proteins (Muscle Protein)
9.
Calcium
10.
Anabolic Agents
Related Therapies and Procedures
1.
Enteral Nutrition (Feeding, Tube)
2.
Transplantation
3.
Total Parenteral Nutrition
4.
Parenteral Nutrition
5.
Injections