3-methylquercetin

01/01/2015 - "Protective effects of isorhamnetin on apoptosis and inflammation in TNF-α-induced HUVECs injury."
08/01/2021 - "The regulatory effect and mechanism of isorhamnetin on influenza virus-mediated inflammation have not yet been reported. "
01/01/2021 - "Isorhamnetin attenuates TNF-α-induced inflammation, proliferation, and migration in human bronchial epithelial cells via MAPK and NF-κB pathways."
07/01/2018 - "In conclusion, these results suggested that isorhamnetin inhibited LPS-induced inflammation in HGFs by activating Nrf2 signaling pathway."
02/01/2016 - "Therefore, the protective effect of isorhamnetin occurs through multiple functions, including anti-inflammation, anti-oxidative stress and anti-apoptosis. "

03/01/2021 - "Our study suggested that the anti-cancer effect of isorhamnetin might trigger paraptosis, which may indicate a new therapeutic approach to OSCC."
07/05/2023 - "The isorhamnetin and anti-PD-L1 antibody dual-functional nanoparticles can improve tumor immune microenvironment and inhibit YY1-mediated tumor progression. "
06/01/2023 - "Isorhamnetin inhibits cell proliferation and the transition of cells from G0/G1 phase to S phase, and tumor sphere formation. "
05/24/2023 - "Regulating diverse cellular signaling pathways makes isorhamnetin a better anti-cancer chemotherapeutic candidate in HCC. "
05/24/2023 - "Isorhamnetin exerts anti-tumor activity in DEN + CCl4-induced HCC mice."

01/04/2023 - "Several studies showed that isorhamnetin has anti-inflammatory and anti-obesity effects. "
12/24/2022 - "This review summarises the main outcomes described in the literature to date, regarding the effects of isorhamnetin on obesity from in vitro and in vivo studies. "
12/24/2022 - "Anti-Obesity Effects of Isorhamnetin and Isorhamnetin Conjugates."
01/18/2016 - "Our results suggest that dietary supplement of isorhamnetin may be beneficial to prevent obesity and steatosis and PPARγ antagonists may be useful to treat hepatic steatosis. "
12/24/2022 - "Further research is needed to increase the scientific evidence referring to this topic; studies in animal models are essential, as well as randomised clinical trials to determine whether the positive results observed in animals could also be found in humans, in order to determine if isorhamnetin and its glycosides can represent a real tool against obesity."

12/22/2022 - "Furthermore, isorhamnetin strongly attenuated AngII-induced left atrial enlargement and atrial fibrosis. "
01/01/2020 - "This study aimed to investigate the cardioprotective potential of isorhamnetin (ISO) in human amniotic epithelial stem cells (hAESCs) through global gene expression analysis and to confirm its beneficial effects on cardiac hypertrophy and fibrosis in the AgII-induced in vivo model. "
07/01/2023 - "Isorhamnetin attenuates the proliferation, invasion, migration and fibrosis of keloid fibroblasts by targeting S1PR1."
11/07/2019 - "Isorhamnetin Alleviates Steatosis and Fibrosis in Mice with Nonalcoholic Steatohepatitis."
05/01/2017 - "Our data demonstrated that isorhamnetin could inhibit cardiac hypertrophy and fibrosis 8 weeks after aortic banding. "

07/01/2019 - "These results show that Isorhamnetin is very critical in Tsoong because Tsoong can down-regulate Hsp70 genes and promote apoptosis of colon cancer cells by inhibiting Hsp70 largely due to the efficacy of Isorhamnetin. "
09/15/2023 - "In this study, human colon adenocarcinoma cells were cultured in the presence or absence of different isorhamnetin concentrations (5-150 μM) for 24 h or 48 h of cultivation to explore the impact on several parameters of viability/proliferation (mitochondrial function using an MTT test, metabolic activity, cell membrane integrity and lysosomal activity using a triple test). "
07/01/2019 - "Isorhamnetin in Tsoong blocks Hsp70 expression to promote apoptosis of colon cancer cells."
03/01/2014 - "Isorhamnetin suppresses colon cancer cell growth through the PI3K‑Akt‑mTOR pathway."
10/27/2010 - "To our knowledge, this is the first report of the effect of isorhamnetin on human colon cancer cells. "