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felbamate (Felbatol)

an orphan drug; used as therapy for the treatment of partial and generalized seizures; structure in first source

Also Known As:

Felbatol; 2-phenyl-1,3-propanediol dicarbamate; ADD-03055; Essex brand of felbamate; Felbamyl; Schering brand of felbamate; Schering-Plough brand of felbamate; Taloxa; W-554; Wallace brand 1 of felbamate; Wallace brand 2 of felbamate; (3-carbamoyloxy-2-phenyl-propyl) carbamate

Networked: 262 relevant articles (56 outcomes, 46 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Alcohols: 387
  - Glycols: 31
    - Propylene Glycols: 2
      - felbamate: 262
- Carboxylic Acids: 83
  - Acyclic Acids
    - Carbamates: 172
      - Phenylcarbamates: 6
        felbamate: 262

Experts

1.	Luszczki, Jarogniew J: 7 articles (01/2008 - 08/2004)
2.	Czuczwar, Stanislaw J: 7 articles (01/2008 - 08/2004)
3.	Czuczwar, S J: 5 articles (09/2006 - 01/2000)
4.	Wielosz, Marian: 4 articles (01/2011 - 07/2003)
5.	Czuczwar, Stanisław J: 4 articles (11/2006 - 05/2003)
6.	Sofia, R Duane: 4 articles (11/2002 - 01/2002)
7.	Czuczwar, Mirosław: 3 articles (06/2014 - 05/2003)
8.	Patsalos, Philip N: 3 articles (12/2013 - 03/2005)
9.	Dieckhaus, Christine M: 3 articles (11/2002 - 06/2002)
10.	Macdonald, Timothy L: 3 articles (11/2002 - 06/2002)

Related Diseases

1.	Seizures (Seizure) 03/01/1997 - "Felbamate monotherapy show a statistical significant improvement in the control of seizures in these patients versus CBZ therapy. " 10/01/2006 - "The past 10 years of clinical experience have demonstrated that when used in accordance with existing recommendations and close clinical monitoring, felbamate is an effective treatment for some patients with seizures refractory to other AEDs. " 01/01/1993 - "Felbamate (FBM) is an effective and safe novel antiepileptic drug (AED) for add-on treatment in adults with refractory partial seizures as shown in three pivotal controlled trials. " 07/01/1994 - "Felbamate may also be safe and effective in patients with generalized, absence, atypical absence, juvenile myoclonic, infantile, and gelastic seizures. " 04/01/1999 - "Felbamate (FBM) was initiated and VPA discontinued for improved seizure control. "
2.	Epilepsy (Aura) 09/01/2008 - "Felbamate is an effective medication for a wide range of epilepsy syndromes in children younger than 4 years. " 01/01/2002 - "Felbamate (FBM; 2-phenyl-1,3-propanediol dicarbamate) is an approved antiepileptic drug shown to be effective in a variety of seizure disorders refractory to other treatments. " 11/01/1991 - "This trial indicates that felbamate is safe and effective in the treatment of comedicated patients with severely refractory epilepsy." 06/01/2010 - "This retrospective study evaluated the efficacy of felbamate in a pediatric population with intractable epilepsy. " 06/01/2010 - "Efficacy of felbamate in the treatment of intractable pediatric epilepsy."
3.	Infantile Spasms (West Syndrome) 03/01/1995 - "Controlled studies are needed to firmly establish that felbamate is both safe and effective for the treatment of infantile spasms. " 10/01/1997 - "Felbamate for refractory infantile spasms." 03/01/1996 - "The use of felbamate to treat infantile spasms." 03/01/1995 - "The use of felbamate to treat infantile spasms." 03/01/1995 - "Based on the initial successful use of felbamate for infantile spasms in an infant with tuberous sclerosis, three additional infants with infantile spasms of different etiologies who had failed conventional therapies were treated with felbamate. "
4.	Partial Epilepsies (Epilepsy, Partial) 09/01/1994 - "Efficacy of felbamate in therapy for partial epilepsy in children." 03/01/1999 - "This open-label study was performed to evaluate efficacy and safety of Felbamate (FBM) add-on therapy in drug-refractory partial epilepsy. " 03/01/1999 - "Felbamate in refractory partial epilepsy." 09/01/1994 - "We conclude that felbamate can be a useful and well-tolerated medication in the treatment of refractory partial epilepsy in children. " 10/01/1994 - "The studies already published allow to expect felbamate to improve substantially the possibilities of antiepileptic pharmacotherapy, since it is an anticonvulsant with a high efficacy in the treatment of partial epilepsy and especially with a very good tolerability. "
5.	Ischemia 07/01/1996 - "In the 100-mg/kg group, blood serum levels were well below 100 microg/mL. These results suggest that felbamate given post hoc is remarkably effective in preventing delayed apoptosis secondary to global ischemia but that effective neuroprotection requires doses higher than those used for anticonvulsant treatment." 07/15/1996 - "We tested the efficacy of felbamate in a gerbil model of transient forebrain ischemia. " 04/01/1999 - "Changes in somatosensory evoked potentials following forebrain ischemia in the gerbils: effects of felbamate." 07/15/1996 - "Protection was moderate when felbamate was used before ischemia. " 07/15/1996 - "There was significant neuronal protection with the use of felbamate, both before and after ischemia in all regions of the brain. "

Related Drugs and Biologics

1.	lamotrigine (Lamictal)
2.	Lennox-Gastaut type Epileptic encephalopathy
3.	topiramate (Topamax)
4.	Vigabatrin
5.	Anticonvulsants (Antiepileptic Drugs)
6.	gabapentin (Neurontin)
7.	tiagabine (Gabitril)
8.	zonisamide (Zonegran)
9.	oxcarbazepine (Trileptal)
10.	etiracetam (levetiracetam)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Ketogenic Diet
3.	Vagus Nerve Stimulation
4.	Ligation
5.	Polypharmacy