matrix Gla protein

79-residue, vitamin K-dependent protein; different from bone Gla protein; contains single disulfide bond & 4.8 gamma-carboxyglutamate (Gla) residues; GenBank X07363 & AF210379 (Bos taurus), Y13903 (Gallus gallus); RefSeq NM_000900 (human), NM_008597 (mouse)

Also Known As:

Networked: 112 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Vermeer, Cees: 15 articles (01/2016 - 10/2007)
2.	Schurgers, Leon J: 12 articles (05/2015 - 01/2007)
3.	Boström, Kristina I: 6 articles (03/2015 - 10/2007)
4.	Yao, Yucheng: 6 articles (03/2015 - 10/2007)
5.	Ataman, O V: 4 articles (01/2015 - 01/2011)
6.	Knapen, Marjo H J: 3 articles (01/2016 - 02/2015)
7.	Krüger, Thilo: 3 articles (05/2015 - 02/2011)
8.	Brandenburg, Vincent M: 3 articles (05/2015 - 05/2010)
9.	Gallieni, Maurizio: 3 articles (08/2014 - 11/2005)
10.	Floege, Jürgen: 3 articles (08/2014 - 08/2004)

Related Diseases

1.	Hypertension (High Blood Pressure) 09/01/2008 - "Renal handling of matrix Gla-protein in humans with moderate to severe hypertension." 09/01/2008 - "Since a decrease in renal clearance is a prevalent clinical problem in patients with hypertension, we aimed to study the renal clearance of matrix Gla-protein from the circulation in these patients having a wide range of creatinine clearances. "
2.	Cardiovascular Diseases (Cardiovascular Disease) 11/01/2013 - "To investigate the relationship of circulating matrix Gla protein (MGP) species with incident cardiovascular disease (CVD) or coronary heart disease (CHD) in type 2 diabetic patients. " 05/01/2015 - "With the discovery that vitamin K-dependent matrix Gla-protein (MGP) is a strong and modifiable factor in the prevention of arterial calcification, vitamin K was put forward as novel treatment option in cardiovascular disease. " 02/01/2014 - "Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease."
3.	Necrosis 05/01/2015 - "Circulating desphospho-uncarboxylated matrix Gla-protein (dp-ucMGP) as well as acute phase markers Interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP), tumour necrosis factor-α (TNF-α) and markers for endothelial dysfunction Vascular Cell Adhesion Molecule (VCAM), E-selectin, and Advanced Glycation Endproducts (AGEs) were measured. " 05/01/2009 - "It is now possible to identify factors clearly favoring the formation of VC: TNF-alpha (which stimulates cell necrosis/apoptosis), CRP, oxidized lipids, AGEs, leptin, inorganic phosphate, high calcium-phosphorus product (CaxPO(4)), calcium, 1,25-OH(2)D(3) and Vitamin D(3), PTHrP (via an intracrine pathway), cyclic AMP, TGF-beta, bone morphogenic protein 2 (BMP2) and factors protective against the formation of VC: magnesium, HDL, inorganic pyrophosphate, albumin, ahsg/fetuin A, osteopontin (OPN), osteoprotegerin (OPG), osteonectin (ON), bone morphogenic protein 7 (BMP7), klotho, PTHrP (via a paracrine pathway), matrix gla protein (MGP), PTH (via Msx2) and vitamin K. "
4.	Kidney Diseases (Kidney Disease) 05/01/2015 - "Plasma protein growth arrest-specific 6 (GAS6) and matrix Gla protein (MGP) are crucial mediators of vascular calcification and are involved in the development of vascular complications in chronic kidney diseases. " 01/01/2011 - "Assessment of matrix Gla protein, Klotho gene polymorphisms, and oxidative stress in chronic kidney disease." 11/01/2005 - "Matrix GLA protein gene polymorphisms: clinical correlates and cardiovascular mortality in chronic kidney disease patients." 04/01/2010 - "The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report." 08/01/2014 - "In chronic kidney disease, vitamin K-dependent proteins, including the calcification inhibitor matrix Gla protein, are largely uncarboxylated indicating that functional vitamin K deficiency may contribute to uremic vascular calcification. "
5.	Vascular Diseases (Vascular Disease) 07/01/2014 - "Desphospho-uncarboxylated matrix Gla-protein is associated with mortality risk in patients with chronic stable vascular disease." 08/20/2010 - "To investigate the effect of altered expression of matrix Gla protein (MGP), an inhibitor of BMP, on vascular disease. " 05/09/2008 - "Arterial calcification is ubiquitous in vascular disease and is, in part, prevented by matrix Gla protein (MGP). " 01/15/2016 - "The abnormal status of uncarboxylated matrix Gla protein species represents an additional mortality risk in heart failure patients with vascular disease." 05/01/2014 - "In this study, we investigated in 79 patients with psoriasis compared to 80 healthy volunteers different biomarkers that play a role in vascular disease and inflammation, such as C-reactive protein (CRP), human soluble CD40 ligand (sCD40L), oxidized low-density lipoprotein (ox-LDL), human matrix Gla protein (MGP) and fetuin-A. "

Related Drugs and Biologics

1.	Vitamin K
2.	alpha-Fetoproteins (AFP)
3.	Osteoprotegerin
4.	Creatinine
5.	Osteopontin
6.	Osteonectin
7.	Calcium
8.	Lipids
9.	Parathyroid Hormone-Related Protein
10.	Leptin

Related Therapies and Procedures

1.	Prostheses and Implants (Prosthesis)
2.	Homologous Transplantation (Allograft)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Renal Dialysis (Hemodialysis)
5.	Drug Therapy (Chemotherapy)