taltrimide

08/01/1990 - "A controlled study with taltrimide and sodium valproate: valproate effective in partial epilepsy."
08/01/1990 - "In partial epilepsy of 7 the seizure frequency was reduced by 27% during valproate (p less than 0.05), compared with placebo, while no improvement was found during taltrimide. "

01/01/1986 - "The anticonvulsive effect of taltrimide observed in animal experiments could not be confirmed in this study; in contrast, the seizures increased statistically significantly during taltrimide treatment. "
01/01/1986 - "The frequency of seizures increased statistically significantly during the trial with increasing dose of taltrimide and decreased again in the withdrawal phase of the trial. "
01/01/1985 - "In the genetically seizure-susceptible rat, taltrimide raised the threshold for audiogenic seizures and decreased seizure severity. "
01/01/1986 - "Of six dropouts, one had status epilepticus, and in two patients increased number or severity of seizures necessitated withdrawal of taltrimide. "
01/01/1985 - "Taltrimide had a greater potency against maximal as compared to minimal seizures, and, at 150 mg/kg, it completely suppressed clonic and myoclonic seizures induced by intracerebroventricular injections of guanidinoethane sulfonate (9.2 ?mol) in rats. "

03/01/1987 - "Taltrimide is a lipophilic taurine derivative with definitive anticonvulsive effects in experimental epilepsy models. "
01/01/1986 - "The antiepileptic effect, effects on EEG, and tolerability of taltrimide, a new taurine derivative, were studied in this open clinical trial in 27 patients with severe epilepsy resistant to conventional drugs. "

01/01/1986 - "Of six dropouts, one had status epilepticus, and in two patients increased number or severity of seizures necessitated withdrawal of taltrimide. "

01/01/2005 - "Taurine derivatives like taltrimide, acamprosate and tauromustine, are already in the market as anti-convulsant, anti-alcoholic and anti-cancer agents. "