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2,2'-azobis(2-amidinopropane) (ABAP)

Subscribe to New Research on 2,2'-azobis(2-amidinopropane)

water-soluble free-radical initiator

Also Known As:

ABAP; 2,2'-azo-bis(2-amidinopropane); 2,2'-azobis(2-amidinopropane) acetate; 2,2'-azobis(2-amidinopropane) dihydrochloride; 2,2'-azobis(2-amidinopropane) monohydrochloride; 2,2'-azobis(2-amidinopropane)dihydrochloride; 2,2'-azobis(2-methylpropionamidine); AAPH; ABAPH; AMPH cpd; Propanimidamide, 2,2'-azobis(2-methyl)

Networked: 165 relevant articles (13 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Amidines: 11
  - 2,2'-azobis(2-amidinopropane): 165

Experts

1.	Liu, Zai-Qun: 17 articles (07/2011 - 03/2002)
2.	Tang, You-Zhi: 7 articles (07/2009 - 03/2007)
3.	Hseu, You-Cheng: 5 articles (04/2014 - 06/2002)
4.	Yang, Hsin-Ling: 5 articles (04/2014 - 06/2002)
5.	Zhou, Bo: 5 articles (06/2013 - 08/2004)
6.	Carvalho, Márcia: 5 articles (09/2011 - 04/2009)
7.	Li, Yan: 4 articles (09/2014 - 11/2011)
8.	Dai, Fang: 4 articles (06/2013 - 04/2006)
9.	Mitjans, Montserrat: 4 articles (10/2007 - 08/2004)
10.	Terasawa, Katsutoshi: 4 articles (05/2005 - 02/2003)

Related Diseases

1.	Hemolysis 12/01/2008 - "In presence of AAPH, hemolysis was significantly greater in HYPO (732.45+/-40% min) and lower in HYPER (578.97+/-15% min) as compared to ISO (608.30+/-42% min). " 01/01/2015 - "However, it provided protection against 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced oxidative hemolysis which declined by 10.2% (p<0.001). " 10/01/2014 - "The present study assessed the antioxidant activity and protective ability of Clitoria ternatea flower petal extract (CTE) against in vitro 2,2'-azobis-2-methyl-propanimidamide dihydrochloride (AAPH)-induced hemolysis and oxidative damage of canine erythrocytes. " 05/01/2005 - "In this study, we demonstrated that Chuling in vitro protects red blood cells from 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH)-induced hemolysis. " 04/01/2005 - "In this study, we demonstrated that ST in vitro protects red blood cells from 2,2-azo-bis (2-amidinopropane) dihydrochloride (AAPH)-induced hemolysis. "
2.	Colonic Neoplasms (Colon Cancer) 09/01/2007 - "HT-29 colon cancer cells were exposed to heat (43 degrees C) in the presence of the ROS-generating drug, 2-2'-azobis-(2-amidinopropane) dihydrochloride (AAPH) for 1 h. " 05/01/2008 - "The objective of this study was to evaluate the efficacy of anthocyanin protection against peroxyl radical (AAPH)-induced oxidative damage and associated cytotoxicity in Caco-2 colon cancer cells. "
3.	Neoplasms (Cancer) 01/01/2004 - "Combinations of NO donors with either ABAP or t-BHP in subtoxic concentrations did not result in marked decrease of tumor cell proliferation. " 06/01/2003 - "Since it is known that cancer cells are generally resistant to physical and chemical stress-induced apoptosis, free radical generators like AAPH appear to be a useful thermosensitizer for hyperthermic cancer therapy." 10/01/1993 - "The 2,2-azo-bis-(2 amidino propane) (AAPH)-initiated lipid peroxidation of rat liver homogenate was inhibited up to 30% and 20% by synthetic and tumor melanin, with half maximal effect at 120 and 500 micrograms melanin/ml, respectively. "
4.	Inflammation 09/01/2013 - "We investigated the protective effects of lucidone, a naturally occurring cyclopentenedione isolated from the fruits of Lindera erythrocarpa Makino, against free-radical and inflammation stimulator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress in human keratinocyte (HaCaT) cells, with the aim of revealing the possible mechanisms underlying the protective efficacy. " 02/01/1992 - "Intrarectal administration of AAPH (60, 90, 150 mg/kg) caused erythema, edema, and histologically verifiable mucosal inflammation. " 04/01/2004 - "Cyclooxygenase-2 (COX-2) appears to play an important role in inflammation and carcinogenesis, and 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) is a hydrophilic azo compound known to generate free radicals. "
5.	Pain (Aches) 03/07/2013 - "CHEE showed a higher protection against lipoperoxidation caused by FeSO4 (82.3% TBARS inhibition) than AAPH (35.7% TBARS inhibition) at 150 μg/mL. Hyptis fruticosa leaf CHEE is of pharmacological interest because it was able to inhibit the peripheral and central transmission of orofacial pain, while reducing the spreading of the inflammatory processes by neutralizing reactive oxygen species, which are by-products in the biosynthesis of pain mediators."

Related Drugs and Biologics

1.	perhydroxyl radical
2.	DNA (Deoxyribonucleic Acid)
3.	Hydroxyl Radical
4.	Curcumin
5.	Anthocyanins (Anthocyanin)
6.	2,2-diphenyl-1-picrylhydrazyl
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Catechin (Z 7300)
9.	Malondialdehyde (Propanedial)
10.	Tea

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Microspheres (Microsphere)
3.	Induced Hyperthermia (Thermotherapy)
4.	Renal Dialysis (Hemodialysis)