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differanisole A

from Chaetomium strain RB-001; structure given in first source

Also Known As:

3,5-dichloro-2-hydroxy-4-methoxy-6-n-propylbenzoic acid

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Chlorobenzoates
        differanisole A: 4
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Chlorobenzoates
        differanisole A: 4

Related Diseases

1.	Neoplasms (Cancer) 03/28/1995 - "The structure of morphogen of Dictyostelium discoideum, DIF-1, which was elucidated by Morris et al. proved to be closely similar to that of differanisole A which had been isolated by us from the metabolites of a simple eucaryote, Chaetomium, as the differentiation-inducer of murine and human undifferentiated tumor cells. " 06/01/1986 - "In vitro and in vivo effects of differanisole A on some tumor cells."
2.	Acute Promyelocytic Leukemia 10/30/1997 - "Differanisole A in combination with 9cisRA may have implications for therapy of acute promyelocytic leukemia patients."
3.	Myeloid Leukemia (Leukemia, Myelocytic) 10/30/1997 - "Differanisole A, 3,5-dichloro-2-hydroxy-4-methoxy-6-n-propylbenzoic acid, inhibited growth of human myeloid leukemia cells. " 10/30/1997 - "Differanisole A, a novel antitumor antibiotic, enhances growth inhibition and differentiation of human myeloid leukemia cells induced by 9-cis retinoic acid."
4.	Leukemia 05/03/1993 - "Differanisole A isolated from the conditioned medium of a soil microorganism, Chaetomium strain RB-001, is an inducer of the differentiation of the Friend leukemic cells (mouse leukemia cells). "

Related Drugs and Biologics

1.	differanisole A
2.	Conditioned Culture Media
3.	Tretinoin (Retinoic Acid)
4.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics