phosphatidylethanolamine drug combination phosphatidylcholine neutral lipid

extracts cholesterol from cellular membranes ; inhibits HIV infection of human peripheral blood lymphocytes or an immortalized helper T-cell line; contains neutral glycerides, phosphatidylcholine & phosphatidylethanolamine in 7:2:1 ratio

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Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	AIDS-Related Complex (ARC) 04/01/1988 - "Open study of AL-721 treatment of HIV-infected subjects with generalized lymphadenopathy syndrome: an eight week open trial and follow-up." 04/01/1988 - "The objective of this open study was to evaluate the effects of AL-721 in vivo in an 8-week open trial in which 10 g twice daily was administered on a low fat diet to eight HIV-infected subjects with lymphadenopathy syndrome (LAS). " 01/01/1991 - "An open-label, dose-ranging trial of AL 721 in patients with persistent generalized lymphadenopathy and AIDS-related complex."
2.	Lymphadenopathy 01/01/1991 - "An open-label, dose-ranging trial of AL 721 in patients with persistent generalized lymphadenopathy and AIDS-related complex." 01/01/1990 - "In five of the nine antigen-positive patients the concentration of HIV antigens was reduced to basal level after about 3 months of AL-721 treatment; three of these responders were asymptomatic, one had persistent generalized lymphadenopathy, and the other had Kaposi's sarcoma. "
3.	Disease Progression 01/01/1991 - "While disease progression was not observed in this short-term study, we could find no indication of an immunorestorative or antiviral effect of AL 721, as determined by T-lymphocyte subset quantitation or HIV culture. "
4.	Kaposi Sarcoma (Kaposi's Sarcoma) 01/01/1990 - "In five of the nine antigen-positive patients the concentration of HIV antigens was reduced to basal level after about 3 months of AL-721 treatment; three of these responders were asymptomatic, one had persistent generalized lymphadenopathy, and the other had Kaposi's sarcoma. "
5.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/1990 - "Improvement of decreased natural killer cell activity in cervical cancer patients by active lipids (AL 721)."

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)
2.	HIV Antigens
3.	Lipids
4.	Antigens

Related Therapies and Procedures

1.	Fat-Restricted Diet (Diet, Fat Restricted)