osthol (osthole)

08/01/2015 - "Our study demonstrated that osthole improved TAA-caused liver injury, fibrogenesis and inflammation in rats. "
12/20/2021 - "Our results suggest a possible role for osthole in the protection against inflammation in the gastrointestinal tract; thus, osthole may be considered as an anti-inflammatory modulator."
02/01/2011 - "Moreover, the histological evaluation of liver specimens demonstrated that the steatosis and inflammation in liver in osthole-treated groups were improved, especially in the 10 mg/kg group (p < 0.05). "
01/01/2018 - "Consistently, the in vivo studies indicated that osthole significantly prolonged the survival of septic mice which was accompanied by inflammation suppression. "
10/01/2023 - "Osthole suppressed inflammation, oxidative stress, apoptosis, and pyroptosis in 16HBE cells, along with a decrease in RIPK2 level. "

06/01/2014 - "Protective effects of osthole on intestinal ischemia-reperfusion injury in mice."
07/01/2013 - "Osthole ameliorates renal ischemia-reperfusion injury in rats."
01/01/2013 - "Osthole ameliorates renal ischemia-reperfusion injury by inhibiting inflammatory response."
05/01/2022 - "Protective effect of osthole on testicular ischemia/reperfusion injury in rats."
04/24/2019 - "Downregulation of miRNA-30a enhanced autophagy in osthole-alleviated myocardium ischemia/reperfusion injury."

01/01/2020 - "The study was aimed at evaluating efficacy of osthole against osteoporosis using high-throughput metabolomics method. "
12/01/2022 - "Osthole is an effective treatment for osteoporosis. "
12/01/2022 - "Recent studies showed its active compound, osthole, had a good effect on osteoporosis. "
01/01/2020 - "Osthole (OST), a derivative of Fructus Cnidii, has been proved to have potential anti-osteoporosis effects in our recent studies. "
03/01/2010 - "Further studies concerning the effects and mechanism of osthole on osteoporotic patients and animals should be performed, as these studies may lead to the development of a drug treatment for osteoporosis in the future."

03/01/2021 - "Osthole ameliorates cognitive impairments via augmenting neuronal population in APP / PS1 transgenic mice."
01/01/2015 - "In this study we found that osthole (30 mg/kg intraperitoneally (i.p.) once daily) treatment dramatically ameliorated the cognitive impairments by Morris Water Maze test and passive avoidance test, and augmented neurogenesis in the DG of hippocampus in APP/PS1 mice. "
06/25/2010 - "This study is to investigate the effects of osthole on cognitive impairment and neuronal degeneration in hippocampus induced by chronic cerebral hypoperfusion in rats, as well as the potential mechanism. "
01/01/2015 - "These observations suggested that osthole promoted NSC proliferation, supported neurogenesis, and thus efficiently rescued impaired neurons in the hippocampus and ameliorated cognitive impairment. "
10/25/2012 - "Results showed that osthole treatment significantly improved cognitive impairment and protected hippocampal neurons of Alzheimer's disease rats. "

03/01/2007 - "To study the effects of osthole on hyperlipidemic fatty liver and investigate the possible mechanisms. "
07/01/2017 - "In addition, cells with OA-induced steatosis were H2O2-stimulated, and then incubated with osthole to evaluated if it could suppress its progression to steatohepatitis. "
05/01/2011 - "Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress."
02/01/2009 - "To examine the inhibitory effect of osthole on alcohol-induced fatty liver in mice and to investigate the potential mechanisms. "
02/01/2009 - "Inhibitory effect of osthole on alcohol-induced fatty liver in mice."