succinyl- leucyl- leucyl- valyl- tyrosyl- methylcoumarinamide

fluorogenic substrate for ingensin

Also Known As:

LLVY-MCA; N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin; SLLVT-MCA; Suc-LLVY-MCA; Suc-Leu-Leu-Val-Tyr-7-amino-4-methylcoumarin; Suc-Leu-Leu-Val-Tyr-MCA

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide: 3

Experts

1.	Davies, K J: 1 article (08/2000)
2.	Doecke, W D: 1 article (08/2000)
3.	Grune, T: 1 article (08/2000)
4.	Huber, M: 1 article (08/2000)
5.	Ladhoff, A: 1 article (08/2000)
6.	Sitte, N: 1 article (08/2000)
7.	Von Zglinicki, T: 1 article (08/2000)
8.	Kiyomiya, K I: 1 article (07/2000)
9.	Kurebe, M: 1 article (07/2000)
10.	Matsuo, S: 1 article (07/2000)

Related Diseases

1.	Hyperoxia 08/01/2000 - "Lysosomal cathepsin-specific activity (using the fluorogenic substrate z-FR-MCA) and cytoplasmic proteasome-specific activity (measured with suc-LLVY-MCA) both declined by 80% or more over 12 wk. Hyperoxia also caused a remarkable increase in lipofuscin/ceroid formation and accumulation over 12 wk, as judged by both fluorescence measurements and FACscan methods. "
2.	Lymphoid Leukemia 07/14/2000 - "An intracellular adriamycin (ADM)-binding protein purified from the cytosol of L1210 mouse lymphocytic leukemia cells had a molecular weight of 700-1500 kDa and hydrolyzed Suc-LLVY-MCA. "
3.	Ischemia 02/01/1996 - "Succinyl-Leu-Leu-Val-Tyr-4-methylcoumaryl-7-amide (Suc-LLVY-MCA) hydrolyzing activities of the 20S and 26S proteasomes in the gerbil cortex following transient forebrain ischemia were examined. "

Related Drugs and Biologics

1.	Proteasome Endopeptidase Complex (Proteasome)
2.	Lipofuscin
3.	Fluorescent Dyes (Fluorescent Probes)
4.	Doxorubicin (Adriamycin)
5.	Ceroid
6.	Cathepsins
7.	Carrier Proteins (Binding Protein)