2,6- di- tert- butyl- 4- hydroperoxy- 4- methyl- 2,5- cyclohexadienone

02/01/1991 - "Since electrophilic species have not been previously postulated to mediate tumor promotion, the present study was undertaken to examine the role of this electrophile in the promoting activity of BHTOOH. "
07/01/1989 - "The metabolism of BHTOOH was examined to assess the role of reactive intermediates in mediating tumor promotion in this tissue. "
05/01/1994 - "In particular, an electrophilic quinone methide is known to mediate both in vivo tumor promotion as well as in vitro cytotoxicity by BHTOOH. "
02/01/1991 - "Together, these data indicate that a quinone methide is mediating tumor promotion by BHTOOH, providing direct evidence that an electrophilic intermediate can elicit this stage of carcinogenesis."
09/01/1988 - "The nature of the skin tumor promotion response to a hydroperoxide metabolite of butylated hydroxytoluene, 2,6-di-tert-butyl-4-hydroperoxyl-2,5-cyclohexadienone (BHTOOH), was examined in SENCAR mice. "

02/01/1991 - "Together, these data indicate that a quinone methide is mediating tumor promotion by BHTOOH, providing direct evidence that an electrophilic intermediate can elicit this stage of carcinogenesis."

09/01/1988 - "Doses of 2, 8, and 20 mumol BHTOOH gave maximal papilloma responses of 0.1, 0.6, and 3.6 papillomas/mouse, respectively. "
09/01/1988 - "Additionally, BHTOOH may enhance the conversion of papillomas to carcinomas. "
09/01/1988 - "The carcinoma:papilloma ratios were 0.08 and 0.40 for the high and intermediate BHTOOH dose groups. "
09/01/1988 - "However, BHTOOH is not a complete carcinogen in that no papillomas or carcinomas were observed in uninitiated mice treated with BHTOOH only."
09/01/1988 - "A similar dose-response relationship for papilloma and carcinoma formation was observed when BHTOOH was applied twice weekly for 50 weeks to mice previously initiated with 7,12-dimethylbenz[a]anthracene. "

09/01/1988 - "Additionally, BHTOOH may enhance the conversion of papillomas to carcinomas. "
09/01/1988 - "The carcinoma:papilloma ratios were 0.08 and 0.40 for the high and intermediate BHTOOH dose groups. "
09/01/1988 - "However, BHTOOH is not a complete carcinogen in that no papillomas or carcinomas were observed in uninitiated mice treated with BHTOOH only."
09/01/1988 - "A similar dose-response relationship for papilloma and carcinoma formation was observed when BHTOOH was applied twice weekly for 50 weeks to mice previously initiated with 7,12-dimethylbenz[a]anthracene. "