HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

hemoglobin Rainier

Tyr replaced by Cys at position 145 on beta chain; abnormality induced by ethylnitrosourea

Also Known As:

Hb Rainier; Hemoglobin Rainier

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        hemoglobin Rainier: 7
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        hemoglobin Rainier: 7

Related Diseases

1.	Polycythemia (Erythrocytosis) 08/01/1985 - "This murine polycythemia is homologous with hemoglobin Rainier in man, in which the amino acid substitution is also beta 145 Tyr----Cys and which is associated with similar physiological consequences." 08/01/1969 - "Regulation of erythropoiesis was studied in affected members of families having either hemoglobin Rainier or Yakima, abnormal hemoglobins associated with erythrocytosis. " 08/01/1969 - "Erythrocytosis associated with hemoglobin Rainier: oxygen equilibria and marrow regulation." 02/16/1968 - "Hemoglobin Rainier, a new hemoglobin variant associated with erythrocytosis, was found in six members of a Caucasiant family. " 01/01/1978 - "Myelofibrosis with complex chromosome abnormality in a patient with erythrocytosis due to hemoglobin Rainier and treated with 32P."
2.	Primary Myelofibrosis (Myelosclerosis) 01/01/1978 - "A patient with familial erythrocytosis associated with Hemoglobin Rainier, and previously treated with 32P, developed myelofibrosis with a hyperdiploid chromosome clone in the myeloid cells (51,XX,+1,2q-(q33),+6,+9,+11,-19,+20q+,+mar 1.) This transformation from a benign disorder of differentiated erythrocytes to a malignant disorder may have been secondary to radiophosphorus therapy." 01/01/1978 - "Myelofibrosis with complex chromosome abnormality in a patient with erythrocytosis due to hemoglobin Rainier and treated with 32P."
3.	Protein S Deficiency (Deficiency, Protein S) 07/01/1994 - "Inherited protein S deficiency and the presence of a rare high oxygen affinity hemoglobin variant: Hb Rainier [beta 145 (HC2) Tyr-->Cys] were found in a family. "
4.	Septic Shock (Toxic Shock Syndrome) 12/01/1996 - "Production of recombinant hemoglobin and especially hemoglobin variants like hemoglobin Rainier has the potential to facilitate use of hemoglobin as a blood substitute as well as in specific applications, such as for use as a therapeutic agent in the treatment of hypotension associated with septic shock."
5.	Hypotension (Low Blood Pressure) 12/01/1996 - "Production of recombinant hemoglobin and especially hemoglobin variants like hemoglobin Rainier has the potential to facilitate use of hemoglobin as a blood substitute as well as in specific applications, such as for use as a therapeutic agent in the treatment of hypotension associated with septic shock."

Related Drugs and Biologics

1.	Hemoglobins (Hemoglobin)
2.	Oxygen (Dioxygen)
3.	Tyrosine (L-Tyrosine)
4.	Histidine (L-Histidine)
5.	Abnormal Hemoglobins
6.	Heme (Haem)
7.	Blood Substitutes (Artificial Blood)
8.	hemoglobin AS

Related Therapies and Procedures

1.	Therapeutics
2.	Cardiopulmonary Bypass (Heart-Lung Bypass)