pro-thyrotropin releasing hormone

found in rat brain; 5 amino acid sequence also in Xenopus skin & bovine hypothalamus

Also Known As:

TRH-Gly-Lys; pGlu-His-Pro-Gly-Lys; pro-TRH; pyroglutamyl-histidyl-prolyl-glycyl-lysine; thyrotropin releasing hormone precursor

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Pyrrolidinones: 162
      - Pyrrolidonecarboxylic Acid: 255
        pro-thyrotropin releasing hormone: 11
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Hypothalamic Hormones: 68
      - Pituitary Hormone-Releasing Hormones: 39
        Thyrotropin-Releasing Hormone: 1449
        pro-thyrotropin releasing hormone: 11

Experts

1.	Alvarez, Azucena L: 2 articles (08/2008 - 05/2007)
2.	García, Silvia I: 2 articles (08/2008 - 05/2007)
3.	Landa, María S: 2 articles (08/2008 - 05/2007)
4.	Pirola, Carlos J: 2 articles (08/2008 - 05/2007)
5.	Schuman, Mariano L: 2 articles (08/2008 - 05/2007)
6.	Calvino, Camila: 1 article (01/2016)
7.	Costa-E-Sousa, Ricardo Henrique: 1 article (01/2016)
8.	Império, Güínever Eustáquio: 1 article (01/2016)
9.	Pazos-Moura, Carmen Cabanelas: 1 article (01/2016)
10.	Souza, Luana Lopes: 1 article (01/2016)

Related Diseases

1.	Hypothyroidism 01/01/2007 - "Our results show that 6-n-propyl-2-thiouracil (PTU) treatment producing hypothyroidism induced a significant increase in the expression of PC1/3, PC2, and pro-TRH in the PVN and LH, but not VMN. " 01/01/2007 - "Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism." 05/01/1991 - "In this location hypothyroidism enhances not only pro TRH synthesis but also release of TRH and another proTRH-derived peptide. " 05/01/1991 - "Hypothyroidism reduces content and increases in vitro release of pro-thyrotropin-releasing hormone peptides from the median eminence." 08/01/1998 - "Fasting results in reduced thyroid hormone levels and inappropriately low or normal thyroid-stimulating hormone (TSH), partly attributed to central hypothyroidism due to suppression of pro TRH gene expression in the hypothalamic paraventricular nucleus. "
2.	Hypertension (High Blood Pressure) 05/01/2007 - "Knocking down the diencephalic thyrotropin-releasing hormone precursor gene normalizes obesity-induced hypertension in the rat." 08/01/2008 - "Thyrotropin-releasing hormone precursor gene knocking down impedes melanocortin-induced hypertension in rats."
3.	Body Weight (Weight, Body) 01/01/2023 - "Compared to fed animals, fasting significantly reduced body weight, PVN pro-TRH messenger RNA (mRNA) and TRH immunoreactivity, but increased NPY mRNA and NPY immunoreactivity in the infundibular nucleus (IN, avian homologue of mammalian arcuate nucleus) and PVN. " 10/01/1994 - "Body weight and temperature, food and water intake, and plasma TSH, T4, free T4 (FT4), T3, and corticosterone levels were measured daily, and hypothalamic pro-TRH messenger RNA (mRNA) and hypophysial TSH beta mRNA were determined after termination of the experiments. "
4.	Coinfection 08/08/1997 - "The addition of 7B2 to the coinfection did not augment the ability of PC2 to cleave pro-TRH to either N- or C-terminal forms."
5.	Obesity 05/01/2007 - "Knocking down the diencephalic thyrotropin-releasing hormone precursor gene normalizes obesity-induced hypertension in the rat."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Thyrotropin (Thyroid-Stimulating Hormone)
3.	Thyroid Hormones
4.	Peptides (Polypeptides)
5.	Corticosterone
6.	Melanocortins
7.	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)
8.	beta Subunit Thyrotropin (Thyrotropin-beta)
9.	Leptin
10.	Triiodothyronine (Liothyronine)