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1,3- dipropyl- 8- (2- amino- 4- chlorophenyl)xanthine
Also Known As:
PACPX; PAPCX
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Xanthines: 123
1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine: 4
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purinones: 2
Xanthines: 123
1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine: 4
Related Diseases
1.
Hyperalgesia
12/01/1995 - "
Similarly, the A1-adenosine antagonist 1,3-dipropyl-8-(2-amino-4- chlorophenyl)-xanthine (PACPX), which had no effect on paw-withdrawal threshold in normal paws, elicited a withdrawal hyperalgesia response in CPA-tolerant paws and cross-withdrawal hyperalgesia responses in DAMGO-tolerant paws.
"
01/01/1990 - "
Adenosine-induced hyperalgesia is mimicked by the A2-agonists, 5'-(N-ethyl)-carboxamido-adenosine and 2-phenylaminoadenosine but not by the A1-agonist, N6-cyclopentyladenosine and antagonized by the adenosine A2-receptor antagonist, PD 081360-0002 but not by the A1-antagonist, 1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine.
"
2.
Bradycardia
12/01/1988 - "
The same order of potency of the antagonists was noted in blocking CHA-induced bradycardia and A1 receptor binding activities (XAC = PACPX greater than 8-PT).
"
3.
Apnea
07/15/1998 - "
The selective A2aAR agonist, 2-p-(2-carboxyethyl) phenethylamino-5'-N-ethylcarboxamido adenosine hydrochloride (CGS 21680), the A3AR agonist, N6-2-(4-aminophenyl) ethyladenosine (APNEA), and the A1AR antagonist, 1,3-dipropyl-8-(2-amino-4-chlorophenyl) xanthine (PACPX) each inhibited TF activity expression induced by TNF, thrombin, or PMA on HUVECs.
"
Related Drugs and Biologics
1.
Adenosine (Adenocard)
2.
Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)
3.
Xanthine
4.
Thrombin
5.
2- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosine
6.
N(6)-cyclopentyladenosine
7.
2-phenylaminoadenosine