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1,3- dipropyl- 8- (2- amino- 4- chlorophenyl)xanthine

Also Known As:

PACPX; PAPCX

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Xanthines: 123
    - 1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Xanthines: 123
        1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine: 4

Related Diseases

1.	Hyperalgesia 12/01/1995 - "Similarly, the A1-adenosine antagonist 1,3-dipropyl-8-(2-amino-4- chlorophenyl)-xanthine (PACPX), which had no effect on paw-withdrawal threshold in normal paws, elicited a withdrawal hyperalgesia response in CPA-tolerant paws and cross-withdrawal hyperalgesia responses in DAMGO-tolerant paws. " 01/01/1990 - "Adenosine-induced hyperalgesia is mimicked by the A2-agonists, 5'-(N-ethyl)-carboxamido-adenosine and 2-phenylaminoadenosine but not by the A1-agonist, N6-cyclopentyladenosine and antagonized by the adenosine A2-receptor antagonist, PD 081360-0002 but not by the A1-antagonist, 1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine. "
2.	Bradycardia 12/01/1988 - "The same order of potency of the antagonists was noted in blocking CHA-induced bradycardia and A1 receptor binding activities (XAC = PACPX greater than 8-PT). "
3.	Apnea 07/15/1998 - "The selective A2aAR agonist, 2-p-(2-carboxyethyl) phenethylamino-5'-N-ethylcarboxamido adenosine hydrochloride (CGS 21680), the A3AR agonist, N6-2-(4-aminophenyl) ethyladenosine (APNEA), and the A1AR antagonist, 1,3-dipropyl-8-(2-amino-4-chlorophenyl) xanthine (PACPX) each inhibited TF activity expression induced by TNF, thrombin, or PMA on HUVECs. "

Related Drugs and Biologics

1.	Adenosine (Adenocard)
2.	Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)
3.	Xanthine
4.	Thrombin
5.	2- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosine
6.	N(6)-cyclopentyladenosine
7.	2-phenylaminoadenosine