avarone

antileukemic agent; isolated from Dysidea avara

Also Known As:

neoavarone; 2,5-Cyclohexadiene-1,4-dione, 2-((1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl-1-naphthalenyl)methyl)-, (1R-(1alpha,2beta,4abeta,8aalpha))-

Networked: 9 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - avarone: 9
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexenes: 4
        avarone: 9

Experts

1.	Novaković, Irena: 2 articles (03/2019 - 08/2016)
2.	Sladić, Dušan: 2 articles (03/2019 - 08/2016)
3.	Kojic, Vesna: 2 articles (03/2018 - 01/2014)
4.	Pejin, Boris: 2 articles (03/2018 - 01/2014)
5.	Tommonaro, Giuseppina: 2 articles (03/2018 - 01/2014)
6.	Kolarević, Stoimir: 1 article (03/2019)
7.	Kostić, Jovana: 1 article (03/2019)
8.	Kračun-Kolarević, Margareta: 1 article (03/2019)
9.	Martinović, Rajko: 1 article (03/2019)
10.	Milovanović, Dragana: 1 article (03/2019)

Related Diseases

1.	Neoplasms (Cancer) 08/08/2016 - "The results showed that strong cytotoxic activity toward cancer cells was improved with simple avarone mimetics. " 08/08/2016 - "Simple avarone mimetics as selective agents against multidrug resistant cancer cells." 10/01/1985 - "dose of avarone increased life span over controls by 146% when treatment was begun 1 day after tumor implantation and by 87% when treatment was delayed until day 8. Avarol, although active, was less effective. " 03/01/2019 - "In this study, mutagenic and genotoxic potential of anti-tumor compounds avarol, avarone, and its derivatives 3'-methoxyavarone, 4'-(methylamino)avarone and 3'-(methylamino)avarone was evaluated and compared to cytostatics commonly used in chemotherapy (5-fluorouracil, etoposid, and cisplatin). "
2.	Lung Neoplasms (Lung Cancer) 01/01/2014 - "According to experimental data obtained, the sesquiterpenoid quinone structure of avarone may inspire development of new drug-like substances with improved cytotoxicity on lung cancer in humans."
3.	Insulin Resistance 02/04/2023 - "Our study demonstrates that avarone, a sesquiterpene quinone obtained from the sponge Dysidea avara, is capable of inhibiting in vitro PTP1B, the main negative regulator of the insulin receptor, while it improves insulin sensitivity, and mitochondria activity in C2C12 cells. "
4.	Glioma (Gliomas) 03/01/2018 - "This study aimed to screen in vitro antitumour activity of the redox couple avarol/avarone against the human malignant glioma cell line U-251 MG for the first time. " 03/01/2018 - "The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells."
5.	Diabetes Complications 02/04/2023 - "In addition, we show that avarone acts as a tight binding inhibitor of aldose reductase (AKR1B1), the enzyme involved in the development of diabetic complications. "

Related Drugs and Biologics

1.	Sesquiterpenes
2.	quinone (benzoquinone)
3.	avarol
4.	Cytostatic Agents
5.	Insulin Receptor
6.	Fluorouracil (Carac)
7.	Cisplatin (Platino)
8.	4'-(methylamino)avarone
9.	Antimitotic Agents
10.	Antimutagenic Agents (Antimutagens)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Topical Administration