seganserin

MW=471.55+72.92; MF=C29-H27-F2-N3-O. 2HCL; structure given in first source

Also Known As:

3-(2-(4-(di-(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-1-methyl-4H-pyridol(1,2-a)-pyridimine-4-one dihydrochloride; R 56413; R-56413; seganserin dihydrochloride; seganserin monohydrochloride; 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-2-methyl-, dihydrochloride

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - seganserin: 4

Experts

1.	Kaur, Gurpreet: 1 article (07/2002)
2.	Kulkarni, Shrinivas K: 1 article (07/2002)

Related Diseases

1.	Acute Liver Failure (Fulminant Hepatic Failure) 07/01/1996 - "The effects of drugs modulating serotoninergic neurotransmission, the nonselective serotonin receptor antagonist methysergide and the serotonin2 receptor antagonist seganserin were tested neuropharmacologically in thioacetamide-induced acute liver failure in rats. "
2.	Thrombocytopenia (Thrombopenia) 03/01/1989 - "At the highest dose tested (2.5 mg/kg body weight) R 56413 was as effective as thrombocytopenia, indicating that 5-HT is the most important platelet-released product that influences tumour cell lodgement."
3.	Sleep Deprivation 11/21/1989 - "During daytime recovery sleep after sleep deprivation, seganserin did not significantly enhance visually scored slow wave sleep (SWS, stages 3 + 4) or the EEG power density in the delta frequencies. " 11/21/1989 - "The effects of seganserin, a specific 5HT2 antagonist, on human sleep were assessed in two experiments and compared to the effects of temazepam and sleep deprivation. "
4.	Hyperphagia (Overeating) 07/12/2002 - "Further, seganserin, 2 mg/kg, i.p., significantly reversed the suppressive effect of fluoxetine and quipazine on progesterone-induced hyperphagia, depression and algesia in hot-plate test. "
5.	Body Weight (Weight, Body) 03/01/1989 - "At the highest dose tested (2.5 mg/kg body weight) R 56413 was as effective as thrombocytopenia, indicating that 5-HT is the most important platelet-released product that influences tumour cell lodgement."

Related Drugs and Biologics

1.	Thioacetamide (Thioacetamid)
2.	Temazepam (Nocturne)
3.	Serotonin Antagonists
4.	Serotonin (5 Hydroxytryptamine)
5.	Quipazine
6.	Progesterone
7.	Methysergide (Sansert)
8.	Fluoxetine (Prozac)