rubimaillin

05/05/2023 - "Mollugin ameliorates murine allergic airway inflammation by inhibiting Th2 response and M2 macrophage activation."
05/05/2023 - "According to our findings, mollugin ameliorated allergic airway inflammation by inhibiting Th2 response and macrophage polarization."
11/16/2022 - "Therefore, the inhibition of this pathway is an important therapeutic target for the treatment of various types of inflammation; (2) Methods: we designed and synthesized 23 mollugin derivatives and evaluated their inhibitory activity against NF-κB transcription; (3) Results: Compound 6d exhibited the most promising inhibitory activity (IC50 = 3.81 µM) and did not show any significant cytotoxicity against the tested cell lines. "
07/01/2019 - "Inflammation of lung tissue was reduced by regulating the NF-κB/MAPK signaling pathway in mollugin treated group."
08/14/2018 - "To overcome these shortfalls, various mollugin derivatives have been synthesized and evaluated for their ability to inhibit U937 monocyte cell adhesion to HT-29 colonic epithelial cells in TNF-α- or IL-6-induced models of colon inflammation. "

07/01/2019 - "In conclusion, data of the study reveals that treatment with mollugin ameliorates Klebsiella pneumonia rat by reducing the lung inflammation. "
07/01/2019 - "Result of the study suggests that water content in lung was reduced in the mollugin treated group compared to pneumonia control group of rats. "
07/01/2019 - "Present study evaluates the protective effect of mollugin against Klebsiella pneumonia (KP) and also postulates the possible mechanism of its action. "
07/01/2019 - "Count of PMNs and WBC were found to be reduced in mollugin treated group compared to pneumonia control group of rats. "
07/01/2019 - "Regulation of NF-κB/MAPK signaling pathway attenuates the acute lung inflammation in Klebsiella pneumonia rats by mollugin treatment."

09/30/2019 - "This study was aimed to investigate the anti-tumor activity of rubimaillin in vitro, and the mechanism involved. "
04/01/2017 - "In the present study, FFJ-3, a structurally modified version of mollugin, an extract of the Traditional Chinese herbal medicine Rubia tinctorum (madder) was used in order to determine the anticancer activity of the compound and investigate the potential mechanisms underlying this effect in human cancer cells. "
07/18/2014 - "Together, these findings support further studies of mollugin as candidate for treatment of human cancer cells. "
07/18/2014 - "In the present study we found that mollugin exhibited cytotoxicity on various cancer models. "
05/01/2013 - "In the present study, we investigated the molecular mechanisms by which mollugin exerts anti-tumor effect in HER2-overexpressing cancer cells. "

05/15/2020 - "This study was aimed to explore the effect of Rubimaillin on the survival, migration, and invasion of prostate cancer cell lines DU145 and PC3, and its mechanism. "
05/15/2020 - "Rubimaillin suppresses proliferation, migration and invasion of prostate cancer cells via the Notch-1/MMP signaling pathway."

09/30/2019 - "These results indicate that rubimaillin is a potential anti-ovarian cancer drug."
09/30/2019 - "Rubimaillin decreases the viability of human ovarian cancer cells via mitochondria-dependent apoptosis."
05/01/2013 - "Our findings suggest that mollugin is a novel modulator of the HER2 pathway in HER2-overexpressing cancer cells with a potential role in the treatment and prevention of human breast and ovarian cancer with HER2 overexpression."
05/01/2013 - "Our results showed that mollugin exhibited potent inhibitory effects on cancer cell proliferation, especially in HER2-overexpressing SK-BR-3 human breast cancer cells and SK-OV-3 human ovarian cancer cells in a dose- and time-dependent manner without affecting immortalized normal mammary epithelial cell line MCF-10A. "