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peripherin

may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim; it is essential for disk morphogenesis; found on neurons in the rodent & human peripheral nervous system; RefSeq NM_008938 (Rds, mouse); NM_013021 (Prph2, rat); NM_000322 (RDS, human); NM_012633 (Prph1, rat); NM_013639 (Prph1, mouse); NM_006262 (PRPH, human)

Also Known As:

PRPH protein, human; Prph1 protein, mouse; Prph1 protein, rat; Prph2 protein, Xenopus; Prph2 protein, human; Prph2 protein, mouse; Prph2 protein, rat; RDS protein, Xenopus; RDS protein, human; Rds protein, mouse; Rds protein, rat; XIF3 protein, Xenopus; peripherin 1 protein, mouse; peripherin 1, rat; peripherin 2, rat; peripherin protein, Xenopus; peripherin protein, human; plasticin protein, Xenopus; plasticin protein, zebrafish; retinal degeneration, slow (retinitis pigmentosa 7), mouse; retinal degeneration, slow protein, human

Networked: 237 relevant articles (1 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Julien, Jean-Pierre: 10 articles (06/2012 - 08/2002)
2.	Robertson, Janice: 8 articles (12/2014 - 03/2003)
3.	Naash, Muna I: 6 articles (11/2014 - 08/2004)
4.	Hoyng, Carel B: 5 articles (11/2008 - 01/2002)
5.	McLean, Jesse R: 4 articles (12/2014 - 02/2008)
6.	Fliesler, Steven J: 4 articles (06/2014 - 08/2004)
7.	Cremers, Frans P M: 4 articles (03/2008 - 01/2002)
8.	Ding, Xi-Qin: 4 articles (01/2006 - 08/2004)
9.	Xiao, Shangxi: 3 articles (12/2014 - 02/2008)
10.	Kriz, Jasna: 3 articles (08/2010 - 08/2002)

Related Diseases

1.	Nevus (Nevi) 12/01/1997 - "Because there are different relative numbers of peripherin-labeled axons throughout NF, PEN, some nevi, and SCH, analysis of peripherin expression may be helpful in the diagnosis of these lesions. " 12/01/1997 - "Neurons and some epithelioid melanocytes, in contrast to type C nevus cells and Schwann cells of NF and SCH, express peripherin, providing further evidence for a transition from a more neuronal to a more schwannian phenotype during the normal maturation sequence of melanocytes in nevi." 03/01/1997 - "The dendritic nevus cells in 15/15 BN also expressed peripherin. " 07/01/1998 - "Specific labeling of tumor cells for peripherin was seen in only 2/5 neuroendocrine skin carcinomas, 3/18 benign nevi and 7/19 melanomas; even in these cases the percentage of tumor cells did not exceed 20%. " 03/01/1997 - "We evaluated by immunohistochemistry 74 cutaneous melanocytic lesions including primary invasive malignant melanoma (IMM), melanoma in situ (MIS), atypical nevus (nevus with architectural disorder and cytologic atypia of melanocytes) (AN), spindle and epithelioid cell nevus (Spitz nevus) (SN), blue nevus (BN), and common intradermal benign melanocytic nevus (BMN) for expression of peripherin. "
2.	Neoplasms (Cancer) 03/01/2008 - "The aim of our present study was to clarify whether peripherin, a type III neuronal intermediate filament, and α-internexin, a type IV neuronal intermediate filament, are expressed in appendiceal well-differentiated endocrine neoplasms. " 09/01/2007 - "The aim of the present study was to clarify the expression of peripherin in human fetal and adult rectal mucosae and rectal well-differentiated endocrine neoplasms and the significance of peripherin expression in well-differentiated endocrine neoplasms. " 03/01/2008 - "It is uncertain whether the expression of peripherin and/or α-internexin is present in the well-differentiated endocrine neoplasms of other organs; further analysis is required to clarify this issue." 03/01/2008 - "Peripherin expression is a common feature of appendiceal and rectal well-differentiated endocrine neoplasms, but the manner of neural marker expression is different depending on the site of origin. " 03/01/2008 - "In all the neoplasms examined, diffuse immunoreactivity of peripherin was observed. "
3.	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/01/1995 - "The authors report a study of polymorphisms in the peripherin-RDS gene in 21 Spanish families affected with Autosomal Dominant Retinitis Pigmentosa and 56 unrelated normal individuals. " 03/01/2010 - "The wild-type peripherin/RDS and the retinitis pigmentosa causing P216L mutant from S2 cells are characterised using circular dichroism (CD) spectroscopy. " 09/01/2005 - "Peripherin/RDS gene polymorphisms (Glu304Gln and Gly338Asp) were found in Indonesian patients with retinitis pigmentosa. " 09/01/2005 - "Peripherin/RDS gene in Indonesian patients with retinitis pigmentosa: geographic comparison of polymorphic variations." 09/01/2005 - "Cone-rod dystrophy, intrafamilial variability, and incomplete penetrance associated with the R172W mutation in the peripherin/RDS gene."
4.	Retinal Diseases 01/01/2006 - "Transgenic animal studies of human retinal disease caused by mutations in peripherin/rds." 04/24/2003 - "This study reveals genetic heterogeneity for BSMD by the identification of a BSMD family, which is not associated with a mutation in the peripherin/RDS gene nor with any other known non-syndromic retinal disease gene." 08/01/2004 - "These findings may have significant implications regarding therapeutic intervention in peripherin/rds-associated retinal diseases." 08/01/2004 - "Mutations in the photoreceptor-specific protein peripherin/rds are associated with multiple retinal diseases. " 04/24/2003 - "In addition, the BSMD phenotype could not be genetically linked to the peripherin/RDS gene, the ROM-1 gene and the four cone genes nor to any of the 42 retinal disease loci. "
5.	Retinal Degeneration 02/01/1991 - "Identification of peripherin as the protein encoded by the normal rds gene and its localization to membranes of rod outer segments will serve as a basis for studies directed toward defining the role of this protein in the morphogenesis and maintenance of the outer segment and toward understanding the mechanism by which the rds mutation causes retinal degeneration." 01/01/2015 - "Novel localization of peripherin 2, the photoreceptor-specific retinal degeneration slow protein, in retinal pigment epithelium." 11/01/2014 - "The peripherin-2 (PRPH2) gene encodes a photoreceptor-specific tetraspanin protein called peripherin-2/retinal degeneration slow (RDS), which is critical for the formation and maintenance of rod and cone outer segments. " 06/15/2014 - "Mutations in the photoreceptor tetraspanin gene peripherin-2/retinal degeneration slow (PRPH2/RDS) cause both rod- and cone-dominant diseases. " 03/01/2011 - "Cone structure in retinal degeneration associated with mutations in the peripherin/RDS gene."

Related Drugs and Biologics

1.	Rhodopsin (Visual Purple)
2.	Vimentin
3.	Antibodies
4.	alpha-internexin
5.	Intermediate Filament Proteins
6.	Proline (L-Proline)
7.	Leucine (L-Leucine)
8.	Choline O-Acetyltransferase (Choline Acetyltransferase)
9.	Codon (Codons)
10.	Retinaldehyde (Retinal)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Transplantation (Transplant Recipients)
4.	Therapeutics