1-alkylglycerophosphocholine acetyltransferase

catalyzes the acetylation of 1-alkyl-sn-glycero-3-phosphocholine in the presence of acetyl-CoA

Also Known As:

1-AGPC-acetyltransferase; Agopc acetyltransferase; PAF acetyltransferase; acetyl CoA-1-alkyl-sn-glcero-3-phosphocholine o-acetyltransferase; acetyl-CoA-2-lyso-PAF acetyltransferase; lyso-PAF - acetyl-CoA acetyltransferase; lyso-PAF-acetyltransferase; lyso-platelet-activating factor-acetyl CoA acetyltransferase; lyso-platelet-activating factor-acetyl-coenzyme A acetyltransferase

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Acetyltransferases: 1040
        1-alkylglycerophosphocholine acetyltransferase: 3

Experts

1.	Cassali, Geovanni D: 1 article (11/2010)
2.	Fagundes, Caio T: 1 article (11/2010)
3.	Garcia, Cristiana C: 1 article (11/2010)
4.	Guabiraba, Rodrigo: 1 article (11/2010)
5.	Machado, Alexandre V: 1 article (11/2010)
6.	Polidoro, Rafael B: 1 article (11/2010)
7.	Russo, Remo C: 1 article (11/2010)
8.	Salgado, Ana Paula C: 1 article (11/2010)
9.	Sousa, Lirlândia P: 1 article (11/2010)
10.	Tavares, Luciana P: 1 article (11/2010)

Related Diseases

1.	Human Influenza (Influenza) 11/04/2010 - "Influenza infection induces the enzyme that synthesizes PAF, lyso-PAF acetyltransferase, an effect linked to activation of TLR7/8. Therefore, it is suggested that PAFR is a disease-associated gene and plays an important role in driving neutrophil influx and lung damage after infection of mice with two subtypes of Influenza A. "
2.	Infections 11/04/2010 - "Influenza infection induces the enzyme that synthesizes PAF, lyso-PAF acetyltransferase, an effect linked to activation of TLR7/8. Therefore, it is suggested that PAFR is a disease-associated gene and plays an important role in driving neutrophil influx and lung damage after infection of mice with two subtypes of Influenza A. "
3.	Hyperinsulinism (Hyperinsulinemia) 05/01/1997 - "Compared to saline-treated rats, sustained physiologic hyperinsulinemia for 7 days: (i) decreased insulin-mediated glucose disposal by 30%; (ii) caused an increased plasma PAF:acetylhydrolase, which degrades PAF to lyso-PAF, without any change in cytosolic PAF:acetylhydrolase activity; and (iii) completely inhibited microsomal lyso-PAF:acetyl CoA acetyltransferase activity which catalyzes the conversion of lyso-PAF back to bioactive PAF. "
4.	Asthma (Bronchial Asthma) 11/01/1996 - "An increase in lyso-PAF acetyltransferase activity alone may not account for increased systemic PAF concentrations during acute asthma. " 11/01/1996 - "Lyso-PAF acetyltransferase activity in neutrophils of patients during acute asthma and after recovery."

Related Drugs and Biologics

1.	1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase)
2.	Insulin (Novolin)
3.	Glucose (Dextrose)
4.	Enzymes
5.	O-deacetyl platelet activating factor