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5-hydroxyuracil

used in treatment of colonic adenocarcinoma

Also Known As:

2,4,5(3H)-Pyrimidinetrione, dihydro-

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Uracil: 1493
        5-hydroxyuracil: 8

Experts

1.	Bidkhori, Mohammad: 1 article (06/2020)
2.	Gholami, Ali: 1 article (06/2020)
3.	Hariri, Mitra: 1 article (06/2020)
4.	Mirhafez, Seyed Reza: 1 article (06/2020)
5.	Sahebkar, Amirhosein: 1 article (06/2020)
6.	Hazra, Tapas K: 1 article (09/2010)
7.	Hegde, Muralidhar L: 1 article (09/2010)
8.	Hegde, Pavana M: 1 article (09/2010)
9.	Holthauzen, Luis M F: 1 article (09/2010)
10.	Mitra, Sankar: 1 article (09/2010)

Related Diseases

1.	Werner Syndrome (Werner's Syndrome) 06/04/2010 - "NEIL1, the mammalian homolog of Escherichia coli endonuclease VIII, is a DNA glycosylase that repairs ring-fragmented purines, saturated pyrimidines and several oxidative lesions like 5-hydroxyuracil, 5-hydroxycytosine, etc. Previous studies from our laboratory have shown that Werner Syndrome protein (WRN), one of the five human RecQ helicases, stimulates NEIL1 DNA glycosylase activity on oxidative DNA lesions. "
2.	Dehydration (Water Stress) 01/01/2008 - "In contrast to cytosine glycols, uracil glycols did not undergo detectable dehydration to 5-hydroxyuracil. " 04/15/1986 - "It is suggested that 5-hydroxyuracil was formed by formic acid-induced deamination and dehydration of cytosine glycol, which was the actual oxidation product of the cytosine moiety in DNA. "
3.	Non-alcoholic Fatty Liver Disease 06/01/2020 - "The enhancement of oxidative stress in non-alcoholic fatty liver disease (NAFLD) patients may cause mutation in DNA by deamination of cytosine to 5-hydroxyuracil or uracil. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 10/01/2002 - "When cells are under oxidative stress that is induced either by oxidizing agents or by mitochondrial dysfunction, additional deamination products such as 5-hydroxymethyluracil (5-HMU) and 5-hydroxyuracil (5-OH-Ura) are formed. "
5.	Neuroblastoma 09/10/2010 - "Here we show that Fe(II/III) and Cu(II) at physiological levels bind to NEIL1 and NEIL2 to alter their secondary structure and strongly inhibit repair of mutagenic 5-hydroxyuracil, a common cytosine oxidation product, both in vitro and in neuroblastoma (SH-SY5Y) cell extract by affecting the base excision and AP lyase activities of NEILs. "

Related Drugs and Biologics

1.	5-hydroxycytosine
2.	RecQ Helicases
3.	DNA Glycosylases (DNA Glycosylase)
4.	A-Form DNA (A-DNA)
5.	Deoxyribonuclease (Pyrimidine Dimer)
6.	Pyrimidines
7.	Purines
8.	Proteins (Proteins, Gene)
9.	Cytosine
10.	DNA (Deoxyribonucleic Acid)