HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
propisomide (pentisomide)
RN from Toxline; RN not in Chemline 8/85; structure given in first source
Also Known As:
pentisomide
; 2-(2-(diisopropylamino)ethyl)-4-methyl-2-(2-pyridyl)pentamide; CM 7857; CM-7857; ME 3202; penticainide
Networked:
13
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Propylamines: 1
propisomide: 13
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
propisomide: 13
Related Diseases
1.
Supraventricular Tachycardia
07/01/1992 - "
Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia.
"
10/01/1990 - "
The electrophysiologic properties of pentisomide indicate that it might be a useful drug in the treatment of supraventricular tachycardia.
"
10/01/1990 - "
[Electrophysiologic effects of penticainide in patients with supraventricular tachycardia].
"
04/01/1996 - "
Serum levels of pentisomide and its metabolite in patients on oral therapy for supraventricular tachycardia are reported.
"
2.
Ventricular Tachycardia
06/01/1990 - "
The aim of this paper is to examine the pentisomide action on selected patients with ventricular tachycardia inducible during intracavitary electrophysiological study.
"
01/01/1995 - "
When pentisomide was infused at 1 mg/kg/min for 20 min, the ventricular tachycardia was significantly reduced at 5 min after starting the infusion; the arrhythmias were reduced to less than 5% at the end of the 20 min infusion.
"
06/01/1990 - "
Ventricular tachycardia inducibility was still inducible after pentisomide, but with a longer cycle length (446 +/- 88 versus 337 +/- 82 msec) than in the basal state (p less than 0.0025).
"
06/01/1990 - "
After the inducibility and the reproducibility of ventricular tachycardia has been assessed in the basal state, all patients underwent several attempts to reinduce ventricular tachycardia, during the i.v. infusion of pentisomide 1.5 mg/kg/5 min followed by continuous infusion of 1 mg/kg/h, at the same time drug plasma level was assessed.
"
11/01/1992 - "
In contrast, higher doses of penticainide failed to inhibit coronary occlusion induced ventricular tachyarrhythmias.
"
3.
Tachycardia (Tachyarrhythmias)
07/01/1992 - "
If intravenous pentisomide did not prevent induction of the tachycardia, oral pentisomide was not effective either.
"
07/01/1992 - "
Intravenous pentisomide prevented tachycardia in 6/9 patients with atrioventricular nodal tachycardia and in 2/6 patients with atrioventricular re-entrant tachycardia.
"
07/01/1992 - "
The electrophysiologic effects of pentisomide were investigated after intravenous (5 mg/kg) and oral (900-1200 mg three times a day) application in 9 patients with drug refractory atrioventricular nodal tachycardia and 6 patients with orthodromic atrioventricular re-entrant tachycardia.
"
10/01/1990 - "
Intravenous pentisomide prevented induction of the tachycardia in 5/9 patients with atrioventricular nodal tachycardia and in 2/6 patients with atrioventricular tachycardia.
"
07/01/1992 - "
Tachycardia cycle length was only increased after intravenous application of pentisomide, antegrade effective refractory periods of the accessory pathways and shortest fully pre-excited R-R intervals during atrial fibrillation were increased after the oral treatment phase (p = 0.054).
"
4.
Body Weight (Weight, Body)
01/01/1994 - "
The pharmacokinetics of penticainide is not modified by the presence of food, but an influence of body weight may be considered.
"
01/01/1994 - "
Influence of food and body weight on the pharmacokinetics of penticainide.
"
07/01/1989 - "
Sixty-one adult mongrel dogs were classified into eight groups according to premedication: 1) control group, physiologic saline solution was administered intravenously 25 min before left anterior descending coronary artery ligation; 2) aprindine group, 3 mg/kg body weight of aprindine intravenously; 3) disopyramide group, 2 mg/kg of disopyramide intravenously; 4) flecainide group, 2 mg/kg of flecainide intravenously followed by drip infusion of 100 micrograms/kg per min; 5) lidocaine group, 2 mg/kg of lidocaine intravenously followed by drip infusion of 100 micrograms/kg per min; 6) mexiletine group, 3 mg/kg per min of mexiletine intravenously followed by drip infusion of 15 micrograms/kg per min; 7) pentisomide group, 5 mg/kg intravenously; and 8) propafenone group, 2 mg/kg intravenously.
"
5.
Coronary Occlusion
11/01/1992 - "
In contrast, higher doses of penticainide failed to inhibit coronary occlusion induced ventricular tachyarrhythmias.
"
Related Drugs and Biologics
1.
Anti-Arrhythmia Agents
2.
Propafenone (Rythmol)
3.
Disopyramide (Norpace)
4.
Mexiletine (Mexitil)
5.
Lidocaine (Xylocaine)
6.
Flecainide (Tambocor)
7.
Amiodarone (Amiodarona)
8.
propisomide (pentisomide)
9.
Aprindine
10.
Saline Solution
Related Therapies and Procedures
1.
Therapeutics
2.
Premedication
3.
Ligation
4.
Intravenous Infusions