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saporin

GenBank X52214

Also Known As:

RIP protein, Saponaria officinalis; SAP5 protein, Saponaria officinalis; SAP6 protein, Saponaria officinalis; ribosome-inactivating protein, S. officinalis; saporin 5 protein, Saponaria officinalis; saporin 6 protein, Saponaria officinalis; saporin protein, Saponaria officinalis; saporin-S9, Saponaria officinalis

Networked: 140 relevant articles (9 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Berg, Kristian: 5 articles (09/2013 - 03/2006)
2.	Fuchs, Hendrik: 4 articles (02/2015 - 02/2007)
3.	Ritter, Sue: 4 articles (10/2013 - 10/2006)
4.	Dinh, Thu T: 4 articles (10/2013 - 10/2006)
5.	Polito, Letizia: 4 articles (10/2013 - 01/2002)
6.	Bolognesi, Andrea: 4 articles (10/2013 - 01/2002)
7.	Porreca, Frank: 3 articles (01/2016 - 05/2007)
8.	Weng, Alexander: 3 articles (02/2015 - 03/2010)
9.	Melzig, Matthias F: 3 articles (02/2015 - 03/2010)
10.	Bachran, Christopher: 3 articles (02/2015 - 02/2007)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2013 - "Saporin-S6: a useful tool in cancer therapy." 12/01/2011 - "Saporin conjugation to JL1 antibody effectively depleted tumor cells in in vitro cytotoxic assays and also prolonged survival in a leukemic mouse model (p < 0.001). " 10/01/2011 - "as well as the toxicity of a saporin based anti-tumor toxin. " 01/01/2009 - "Plasmids expressing a cytosolic saporin (SAP) gene from common soapwort (Saponaria officinalis) are generated by placing the region encoding the mature plant toxin under the control of strong viral promoters and may be placed under tumor-specific promoters. " 09/01/2007 - "Saporin is a type I ribosome-inactivating protein that is often appended with a cell-binding domain to specifically target and kill cancer cells. "
2.	Hodgkin Disease (Hodgkin's Disease) 03/01/1996 - "The anti-CD30 immunotoxin (IT) Ber-H2/saporin is effective in patients with refractory Hodgkin's disease. " 05/01/2009 - "The purpose of this work was to compare the pathways of cell death induced by the RIP saporin with those carried out by ricin in the L540 human Hodgkin's lymphoma-derived cell line. " 09/01/1998 - "Targeting of saporin to Hodgkin's lymphoma cells by anti-CD30 and anti-CD25 bispecific antibodies." 10/01/1995 - "Among CD25-CD30+ Hodgkin's lymphoma lines, which were resistant to targeting by anti-CD25/saporin BsmAb, one (L428) was sensitive to both gelonin and saporin delivered by anti-CD30 BsmAb. " 10/01/1994 - "A Ber-H2/saporin immunotoxin, consisting of the single-chain ribosome-inactivating protein saporin-S6 and the anti-CD30 monoclonal antibody Ber-H2, gave encouraging results in the treatment of refractory Hodgkin's disease but caused a transient hepatotoxicity. "
3.	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 08/01/1991 - "These studies have clearly demonstrated the effectiveness of this BsAb for delivering saporin to a T-ALL cell line utilising CD7 as the target molecule on the cell surface. " 08/01/1994 - "A SCID mouse model of human T-ALL has been used to determine the in vivo therapeutic efficacy of two anti-CD7-saporin immunotoxins constructed with either a hindered (HB2-SMPT-Sap) or non-hindered (HB2-SPDP-Sap) disulphide bond between antibody and saporin. " 04/01/1992 - "We have investigated the effectiveness of three different F(ab' gamma)2 bispecific antibodies (BsAb) for delivering the ribosome inactivating protein (RIP) saporin via the CD7 or CD38 cell surface molecules to the human T-ALL cell lines HSB-2 and HPB-ALL. " 12/15/1998 - "We have investigated the anti-leukemia effect that is exerted by the murine anti-CD7 antibody HB2 in a severe combined immunodeficient (SCID) mouse model of human T-cell acute lymphoblastic leukemia (T-ALL) and determined the contribution that this antibody effect makes to the therapeutic potency of a saporin immunotoxin (IT) constructed with the same antibody. "
4.	Lymphoma (Lymphomas) 01/01/1994 - "Terminal lymphoma was treated with bispecific antibody (BsAb) which recruits the ribosome-inactivating protein saporin. " 01/01/1992 - "Initial experience in treating human lymphoma with a combination of bispecific antibody and saporin." 11/15/1988 - "Bispecific F(ab' gamma)2 antibody for the delivery of saporin in the treatment of lymphoma." 09/01/2006 - "Conjugation of the sialoside probes to the toxin saporin resulted in toxin uptake and toxin-mediated killing of B lymphoma cell lines, suggesting an alternative approach for targeting CD22 for treatment of B cell lymphomas." 05/01/2009 - "Saporin induces multiple death pathways in lymphoma cells with different intensity and timing as compared to ricin."
5.	AIDS-Related Complex (ARC) 01/01/2003 - "Saporin-conjugated anti-dbetah virtually eliminated dbetah-immunoreactive terminals in the ARC without causing nonspecific damage. " 10/15/2013 - "We tested this hypothesis using saporin toxin conjugated to leptin (Lep-SAP) injected into Arc in rats. " 11/01/2011 - "We examined the role of neuropeptide Y (NPY) receptor-expressing neurons in the mediobasal hypothalamus (MBH) in this process by injecting the targeted toxin, NPY-saporin (NPY-SAP), into the arcuate nucleus (Arc). " 04/06/2010 - "This was accomplished either by microinjecting NPY conjugated to saporin (NPY-SAP) bilaterally into the Arc to kill NPY receptor-bearing neurons or via neonatal monosodium glutamate (MSG) treatment. " 06/01/2012 - "We used the targeted toxin, leptin conjugated to saporin (Lep-SAP), to examine the importance of leptin receptor-B (LepR-B)-expressing neurons in the arcuate nucleus (Arc) for generation of circadian feeding rhythms. "

Related Drugs and Biologics

1.	Immunotoxins (Immunotoxin)
2.	substance P-saporin
3.	Substance P
4.	Saponins
5.	Antigens
6.	Cholera Toxin
7.	Bispecific Antibodies
8.	Gelonium multiflorum GEL protein
9.	Neuropeptides
10.	Fibroblast Growth Factors (Fibroblast Growth Factor)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Ligation
3.	Spinal Injections
4.	Injections
5.	Transplants (Transplant)