K-18 conjugate (K18)

11/01/2023 - "Upper Respiratory Infection Drives Clinical Signs and Inflammatory Responses Following Heterologous Challenge of SARS-CoV-2 Variants of Concern in K18 Mice."
09/01/2023 - "These new hACE2 transgenic strains display high permissiveness to the replication of SARS-CoV-2 Omicron sub-variants, while the previously available B6.K18-ACE22Prlmn/JAX mice have been reported to be poorly susceptible to infection with Omicron. "
01/01/2022 - "Intranasal infection of K18 human ACE2 transgenic mice (K18-hACE2) with SARS-CoV-2 resulted in lung pathology associated with viral replication and immune cell infiltration. "
11/17/2021 - "Intranasal infection of K18 human ACE2 transgenic mice (K18-hACE2) with SARS-CoV-2 resulted in lung pathology associated with viral replication and immune cell infiltration. "
09/01/2021 - "The acetylation level for K18 especially was up-regulated approximately 7.4 times after 36 h of post-infection. "

05/01/1986 - "This remarkable efficacy and low degree of side effects in clinical application is probably due to the higher affinity and accumulation of K18 in the tumor region. "
03/01/1990 - "A distribution study clarified the unique properties of K18 to accumulate and remain in the tumor site with a high rate."
02/01/1988 - "[Clinical phase II study of K-18 in cancer of the digestive organs]."
05/01/1986 - "In a study of distribution after K18 administration, the accumulation and retention of this drug in the tumor region were observed. "
11/01/2012 - "Real-time analysis of tumor samples from engrafted animals, MAC 51, metastatic liver and metastatic ovary revealed overexpression of K8 and K18 compared to the respective controls. "

05/31/2023 - "Furthermore, we evaluated the efficacy of MDB-601a-NM in protecting against SARS-CoV-2 infection using the K18 hACE-2 transgenic mouse model. "
01/01/2023 - "Preclinical studies of coronavirus disease 19 (COVID-19) pathogenesis have used several animal species as models: transgenic human ACE2 mice (K18 mice), inbred BALB/c or C57BL/6N mice, ferrets, minks, domestic cats and dogs, hamsters, and macaques. "
08/01/2023 - "Selected compounds were formulated as solutions for nebulization and, after being characterized in terms of aerosolization performance and droplet size distribution, their efficacy was assessed in vivo using the K18 human (h)ACE2 transgenic mouse model of SARS-CoV-2 infection."
01/01/2022 - "Here, we report on SARS-CoV-2 infection of hamsters engineered to express the hACE2 receptor under the control of the K18 promoter. "
01/01/2021 - "Methods: To address these questions, we studied SARS-CoV-2-infected K18-hACE2 (K18) mice, a severe COVID-19 mouse model, as well as lung samples from SARS-CoV-2-infected nonhuman primates (NHP) and patient deceased from COVID-19. "

04/01/2012 - "Moreover, studies showed an association of K8/K18 variants with human acute and chronic liver diseases. "
01/01/2022 - "Twenty-two miRs were associated with the other liver disease category or with K18 measurements. "
05/01/2012 - "K8/K18 variants are found in approximately 4% of white population and predispose to development and adverse outcome of multiple liver diseases. "
09/01/2010 - "Mutations in K8 and K18 predispose the affected individual to liver disease as they protect hepatocytes from apoptosis. "
08/01/2009 - "K8/K18/K19 variants are overrepresented in Italian PBC patients and associate with liver disease progression. "

11/01/2007 - "These findings are supported by extensive transgenic mouse and ex vivo primary hepatocyte culture studies showing that K8 or K18 mutations predispose the liver to acute or subacute injury and promote apoptosis and fibrosis. "
01/01/2019 - "In conclusion, measurements of serum K18 or cK18 in HBV decompensated cirrhosis are a promising tool for predicting ACLF and risk stratification of short-term outcome."
03/24/2010 - "Site-specific phosphorylation of K18 was determined in livers of twelve healthy donors, and non-cirrhosis (n = 40) and cirrhosis (n = 21) patients. "
05/23/2022 - "Theragnostic Efficacy of K18 Response in Alcohol Use Disorder with Clinically Significant Fibrosis Using Gut-Liver Axis."
10/18/2012 - "The importance of K8/K18 in alcoholic liver disease as well as in established cirrhosis remains unknown. "