hevein

43-amino acid residue protein from the rubber tree; homology with thionins and WHEAT GERM AGGLUTININS; not strictly a lectin since it does not act as an agglutinin but has the hevein motif characteristic of lectins;

Also Known As:

Networked: 21 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Istomina, Ekaterina A: 1 article (05/2021)
2.	Kasianov, Artem S: 1 article (05/2021)
3.	Konopkin, Alexey A: 1 article (05/2021)
4.	Korostyleva, Tatyana V: 1 article (05/2021)
5.	Kovtun, Alexey S: 1 article (05/2021)
6.	Odintsova, Tatyana I: 1 article (05/2021)
7.	Shcherbakova, Larisa A: 1 article (05/2021)
8.	Slezina, Marina P: 1 article (05/2021)
9.	Adhami, Farzaneh: 1 article (01/2011)
10.	Allwardt, Dorothee: 1 article (01/2011)

Related Diseases

1.	Hypersensitivity (Allergy) 01/01/1997 - "Finally the DR4-DQ8 haplotype frequency was significantly elevated in hevein-positives when compared with hevein-negatives (51% vs. 0, p = 0.0003, pc = 0.034) or controls (51% vs. 18%, p = 0.0002, pc = 0.045) The present data suggest DR4 and DQ8 to be operating jointly as susceptibility factor for the allergy to hevein." 01/01/2011 - "Among hevein-sensitized, latex-allergic patients, the percentage of plant food allergy (15/34 = 44%) was equal to latex-allergic patients without hevein sensitization (11/25 = 44%). " 01/01/2011 - "We aimed to assess the extent of cross-reactivity between hevein and HLDs using sera from latex-allergic patients with and without plant food allergy. " 09/01/2002 - "Because the genetically determined susceptibility is one important factor regulating type I allergy, the association between the hevein-specific IgE immune response and HLA class II alleles of DQB1 and DRB1, DRB3, DRB4, and DRB5 was studied. " 05/01/1999 - "Inhibition experiments using isolated hevein and CBAPs as inhibitor solutions were performed to study the immunological cross-reactivity between both protein species and to assess the role of the CBAPs as mediators in latex-associated avocado allergy. "
2.	Latex Hypersensitivity (Latex Allergy) 09/01/2002 - "HLA data analysis revealed significantly increased phenotype frequencies for DQB1*0302 (DQ8; 91/189 [48%]) and DRB1*04 (DR4; 102/189 [54%]) in hevein-positive HCWs with latex allergy compared with the 80 hevein-negative HCWs with latex allergy (DQB1*0302: 16/80 [20%], corrected P value [P (c)] = 7.1 x 10(-4); DRB1*04: 23/80 [29%], P (c) =.01) and with control subjects (DQB1*0302: 16/89 [18%], P (c) = 1 x 10(-4); DRB1*04: 22/90 [24%], P (c) = 3.2 x 10(-4)). " 03/01/1997 - "Skin prick testing showed a positive reaction to hevein in 17 of 21 (81%) patients with latex allergy. " 09/01/2002 - "The DQB1*0302 (DQ8) alone, the DQB1*0302 (DQ8)-DRB1*04 (DR4) haplotype, or both are significantly involved in the hevein-specific IgE immune response in HCWs with latex allergy." 09/01/1998 - "Hevein is the major cross-reacting allergen with avocado in subjects with latex allergy." 02/15/2004 - "Hevein with a highly reduced ability to bind IgE should provide a valuable candidate molecule for immunotherapy of latex allergy and is anticipated to have a low risk of systemic side effects."
3.	Wounds and Injuries (Trauma) 11/01/1993 - "The predicted protein is approximately 70% identical to hevein, to the wound-inducible WIN1 and WIN2 proteins from potato, and to PR-4, a pathogenesis-related protein from tobacco." 08/01/1993 - "Wheatwin1 is highly homologous (95%) to barwin, a protein from barley seed, which was shown to be related to the C-terminal domain of two proteins encoded by the wound-induced genes win1 and win2 in potato and to a protein encoded by the same domain of the hevein gene (hev1) in rubber tree. " 11/01/1991 - "The proteins are highly similar to putative wound-induced proteins of potato (win) and to the precursor protein of hevein. " 10/01/1990 - "Wound-induced accumulation of mRNA containing a hevein sequence in laticifers of rubber tree (Hevea brasiliensis)." 09/22/1992 - "Barwin is closely related to a peptide segment of 122 residues at the C-terminal region of the proteins encoded by two wound-induced genes in potato plants, win1 and win2, and a protein encoded by the hevein gene of rubber tree. "
4.	Spinal Dysraphism (Spina Bifida) 09/01/2002 - "The distribution of HLA-DQB1 and DRB1, DRB3, DRB4, and DRB5 in 269 HCWs with latex allergy, 56 latex-sensitized patients with spina bifida (SB), and 90 nonatopic control subjects under special consideration for hevein-specific IgE was examined. " 11/01/1998 - "In latex-sensitive adults, hevein (Hev b6), rubber elongation factor (Hev b1) and Hev b5 are reported as major allergens, while in children with spina bifida, latex particle proteins are important allergens. " 03/01/1997 - "Specific IgE antibodies to hevein were detected by enzyme-linked allergosorbent test in 48 of 64 (75%) sera from health care workers allergic to latex and in three of 11 (27%) sera from patients with spina bifida and hypersensitivity reactions to latex. " 11/01/1997 - "While hevein (Hev b 6.02) is the major allergen in latex-allergic health care workers, 80% of latex sensitized-spina bifida children have IgE antibodies to the "rubber elongation factor" (Hev b 1). "
5.	Infections 05/27/2021 - "We discovered a novel type of 10-Cys-containing hevein-like AMPs named SlHev1, which was up-regulated both by infection and elicitors. " 11/01/1993 - "This hevein-like (HEL) mRNA was inducible by either turnip crinkle virus infection or ethylene treatment. "

Related Drugs and Biologics

1.	Latex
2.	Immunoglobulin E (IgE)
3.	Proteins (Proteins, Gene)
4.	Allergens
5.	Peptides (Polypeptides)
6.	HLA-DRB1 Chains (HLA DRB1)
7.	Oligonucleotide Probes
8.	Antibodies
9.	Peptide Elongation Factors (Elongation Factor)
10.	Chitinases

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Immunotherapy