arsenic trisulfide (orpiment)

01/22/2016 - "Arsenic sulfide (AS) has excellent cytotoxic activity in acute promyelocytic leukemia (APL) but its activity in solid tumors remains to be explored. "
01/01/2009 - "Realgar (arsenic sulfide, As(4)S(4)) has been shown to have clinical efficacy in patients with newly diagnosed and relapsed acute promyelocytic leukemia. "
12/01/2008 - "The clinical efficacy and safety of realgar (arsenic sulfide, As(4)S(4)) in the treatment of acute promyelocytic leukemia in China have given rise to an upsurge in research on the underlying mechanism. "
08/19/2008 - "To analyze the effect of additional chromosome abnormalities on the prognosis and the clinical manifestations of acute promyelocytic leukemia (APL) and the reaction of the patients with additional chromosomes to the treatment of combination of red arsenic sulfide, all trans-retinoic acid (ATRA) and anthracyclin. "
08/19/2008 - "[Effect of additional chromosome abnormalities on the outcome of newly diagnosed acute promyelocytic leukemia treated with red arsenic sulfide and all trans-retinoic acid plus anthracyclin based protocol]."

08/01/2007 - "It is concluded that the pnas-2 gene may be closely related with apotosis of arsenic sulfide treated APL cells, and may consider as a molecular biological remission marker in acute leukemia."
02/01/2007 - "Preparation of orpiment nanoparticles and their cytotoxic effect on cultured leukemia K562 cells."
01/01/2003 - "Red orpiment inhibits the proliferation of leukemia cells by inducing them to undergo apoptosis."
09/01/2001 - "It was concluded that, red orpiment induced PML to play the effects of induce apoptosis in leukemia cells at the translational level and inhibited the proliferation of leukemia cells."
12/01/2015 - "Prohibitin promotes apoptosis of promyelocytic leukemia induced by arsenic sulfide."

06/10/2023 - "Arsenic sulfide (As4S4) nanoparticles have been intensively researched as a promising drug in a cancer treatment. "
02/01/2007 - "Thus, orpiment nanoparticles can produce a much better cytotoxic effect on cancer cells than that of traditional orpiment."
01/01/2019 - "This study aimed at investigating the anti-tumor effect of arsenic sulfide (As2S2) against liver cancer both in vivo and in vitro and to elucidate its underlying mechanisms. "
12/10/2019 - "Arsenic sulfide was found to have potential anti-cancer activities, especially in gastric cancer. "
01/22/2016 - "Arsenic sulfide (AS) has excellent cytotoxic activity in acute promyelocytic leukemia (APL) but its activity in solid tumors remains to be explored. "

01/01/2019 - "Arsenic sulfide nanoformulation induces erythroid differentiation in chronic myeloid leukemia cells through degradation of BCR-ABL."
03/03/2009 - "In this study, we show that combined use of Imatinib (IM) and arsenic sulfide [As(4)S(4) (AS)] exerts more profound therapeutic effects in a BCR/ABL-positive mouse model of chronic myeloid leukemia (CML) than either drug as a single agent. "

07/01/2013 - "The aim of this study was to investigate the effects of arsenic sulfide (As2S2), the main ingredient of realgar, on the proliferation and apoptosis of the Raji B-cell lymphoma and Jurkat T-cell lymphoma lines, comparing the sensitivity between the two cell lines and investigating the possible underlying mechanisms. "