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GM2 N-glycolylneuraminic acid ganglioside

Also Known As:

GM2(NeuGc); GalNAc(1-4)NeuGc(2-3)Gal(1-4)Glc(1-1)Cer

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Neoplasms (Cancer) 02/01/1994 - "Although GM3-NeuAc was the major ganglioside in both the solid tumor and cultured tumor cells, several gangliosides expressed in the solid tumors (e.g., GM2-NeuGc, GM1, and GM1b) were not expressed in the cultured tumor cells. " 03/01/1987 - "GM2(NeuGc), however, could not be detected in either meconium or fetal tissues so far examined, suggesting that this unique ganglioside is a tumor-specific antigen, at least for human intestinal tissues."
2.	Colonic Neoplasms (Colon Cancer) 03/01/1987 - "In order to detect and determine specifically GM2(NeuGc) on human colon cancers, specific antibody against GM2 (NeuGc) has been prepared by immunizing chickens. " 03/01/1987 - "Like usual GM2 ganglioside containing N-acetylneuraminic acid (NeuAc) isolated from Tay-Sachs brain, GM2(NeuGc) in colon cancer could be converted into GM3(NeuGc) by human kidney beta-N-acetylhexosaminidase A in the presence of a GM2-specific activator protein isolated from guinea pig kidney. "

Related Drugs and Biologics

1.	Gangliosides
2.	Hexosaminidase A (Hex A)
3.	N-Acetylneuraminic Acid (Sialic Acid)
4.	Proteins (Proteins, Gene)
5.	G(M2) Ganglioside (Ganglioside GM2)
6.	Antigens
7.	ganglioside M1b (GM1b)