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miglitol (Glyset)

RN given refers to parent cpd(D)-isomer

Also Known As:

Glyset; BAY m 1099; BAY-m 1099; BAY-m-1099; Diastabol; Lacer brand of miglitol; N-hydroxyethyl-1-desoxy-nojirimycin; N-hydroxyethyl-1-desoxynojirimycin; Plumarol; Sanofi-Synthelabo brand of miglitol; miglitol, 4-methylbenzenesulfonate salt, ((D)-isomer)

Networked: 94 relevant articles (17 outcomes, 23 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Goda, Toshinao: 10 articles (09/2014 - 10/2007)
2.	Mochizuki, Kazuki: 10 articles (09/2014 - 10/2007)
3.	Fuchigami, Masahiro: 6 articles (09/2014 - 12/2009)
4.	Fukaya, Nanae: 6 articles (11/2011 - 06/2009)
5.	Tanaka, Yutaro: 4 articles (11/2011 - 07/2009)
6.	Terauchi, Yasuo: 3 articles (11/2014 - 01/2010)
7.	Osonoi, Takeshi: 3 articles (09/2014 - 12/2010)
8.	Saito, Miyoko: 3 articles (09/2014 - 12/2010)
9.	Fujiwara, Hisayoshi: 3 articles (09/2011 - 07/2004)
10.	Minatoguchi, Shinya: 3 articles (09/2011 - 07/2004)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 03/01/2000 - "Clinical trials with miglitol (usually 50 or 100 mg 3 times daily) in patients with type 2 diabetes mellitus consistently demonstrated a significant improvement in glycaemic control for periods of 6 to 12 months. " 11/01/2000 - "Miglitol is an effective and safe treatment option in patients with type 2 diabetes mellitus who are inadequately controlled with diet or oral sulfonylurea therapy. " 05/01/1997 - "Miglitol monotherapy is effective and safe in NIDDM patients. " 03/01/2011 - "Results of this study indicate that miglitol significantly improves metabolic control in Chinese patients with type 2 diabetes mellitus. " 03/01/2011 - "The objective of this study is to examine the efficacy and tolerability of miglitol with respect to improving glycemic control in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylurea treatment. "
2.	Hyperglycemia 01/01/2012 - "In conclusion, 3-month repeated administration of miglitol improved vascular endothelial dysfunction by strongly suppressing postprandial hyperglycemia. " 07/01/1986 - "Thus, in a one-day study 50 mg of Bay m 1099 reduced the postprandial hyperglycemia in NIDDs. " 12/13/2012 - "Furthermore, α-1-C-butyl-LAB strongly suppressed postprandial hyperglycemia at an early phase, similar to miglitol in vivo. " 06/05/2011 - "Thus, combined treatment with the α-GI miglitol, which more strongly inhibits the early phase of postprandial hyperglycemia, and DPP4 inhibitor yields both complementary and synergistic effects, and might represent a superior anti-hyperglycemic therapy. " 01/01/2011 - "Miglitol has been shown to have a beneficial effect on postprandial hyperglycemia in diabetic patients. "
3.	Obesity 01/01/2015 - "Overall, we demonstrate that miglitol shows good potential as a therapeutic for the treatment of obesity. " 01/01/2014 - "Recent studies have shown that miglitol reduces obesity in humans and rodents. " 01/01/2015 - "In this review, we provide an overview of the state of research on miglitol for obesity treatment, emphasizing that it warrants more detailed attention. " 01/01/2015 - "Among these results, we consider that BAT activation is likely the definitive mediator of miglitol's anti-obesity effect. " 01/01/2015 - "Review: Miglitol has potential as a therapeutic drug against obesity."
4.	Hypoglycemia (Reactive Hypoglycemia) 01/01/2004 - "A decrease in the number of hypoglycemia episodes (39.4% previous quarter versus 3% quarter wih miglitol) was observed. " 11/28/2014 - "Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy." 11/28/2014 - "In this report, we propose a new therapeutic approach for reactive hypoglycemia after gastrectomy, namely, administration of miglitol 30 min before meals." 11/28/2014 - "Since hypoglycemia following gastrectomy is thought to be caused by rapid delivery of nutrients into the duodenum, we performed a meal tolerance test while varying the timing of administration of miglitol in relation to the meal. " 01/01/2012 - "In conclusion, the administration of miglitol was effective for preventing reactive hypoglycemia secondary to late dumping syndrome."
5.	Insulin Resistance 11/01/2007 - "Body mass index (BMI) tended to decrease with miglitol (P = .06), and homeostasis model assessment of insulin resistance and AER significantly decreased (P < .05 and P < .001, respectively) with miglitol; these changes were not obtained with mitiglinide. " 06/01/1999 - "Glucose tolerance and insulin resistance in the JCR:LA-corpulent rat: effect of miglitol (Bay m1099)." 01/01/2015 - "Miglitol has been shown to reduce body weight and ameliorate insulin resistance in both clinical trials with adult patients and in rodent models of obesity. " 05/01/2013 - "The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice." 11/01/2007 - "The present comparative study indicated favorable effects of miglitol on BMI, homeostasis model assessment of insulin resistance, adiponectin, and AER, which are markers related to insulin resistance and atherosclerosis. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	alpha-Glucosidases (Acid Maltase)
3.	Glucose (Dextrose)
4.	Glucosidases
5.	Acarbose
6.	voglibose
7.	Incretins
8.	sitagliptin (Januvia)
9.	Interleukin-18 (Interleukin 18)
10.	Glucagon-Like Peptide 1 (GLP 1)

Related Therapies and Procedures

1.	Gastrectomy
2.	Exercise Therapy (Therapy, Exercise)
3.	Oral Administration