HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
CI 922
inhibits IgE induced release of histamine
Also Known As:
3,7-dimethoxy-4-phenyl-N-(1H-tetrazol-5-yl)-4H-furo-(3,2-b)-indole-2-carboxamide 1-arginate; CI-922; L-Arginine, compd. with 3,7-dimethoxy-4-phenyl-N-1H-tetrazol-5-yl-4H-furo(3,2-b)indole-2-carboxamide
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Tetrazoles: 14
CI 922: 2
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
CI 922: 2
Related Diseases
1.
Myocardial Infarction
01/01/1988 - "
This study was performed to assess the effect of Ci-922, an inhibitor of neutrophil activation, in a canine preparation of myocardial infarction.
"
2.
Bronchial Spasm
01/01/1987 - "
CI-922 (0.3 mg/kg, i.v.) also reduced the bronchospasm caused by aerosol antigen (ascaris) challenge in spontaneously allergic dogs.
"
01/01/1987 - "
CI-922 did not show direct antagonist activity when tested against a serotonin-induced bronchospasm, and exhibited only slight activity against a histamine-induced bronchospasm.
"
3.
Anaphylaxis (Anaphylactic Shock)
01/01/1987 - "
In rats, CI-922 given immediately before antigen challenge (ID50 of 0.29 mg/kg, i.v.) was effective and twice as potent as cromolyn sodium and twenty times more potent than proxicromil in preventing i.v. antigen-induced pulmonary anaphylaxis.
"
Related Drugs and Biologics
1.
Serotonin (5 Hydroxytryptamine)
2.
Histamine (Histamine Dihydrochloride)
3.
Cromolyn Sodium (Cromoglicic Acid)
4.
Antigens
5.
Aerosols
6.
proxicromil