3,6-bis(2-piperidinoethoxy)acridine trihydrochloride

immunomodulator; structure given in first source; RN given for tri-HCl

Also Known As:

3,6-bis(2-piperidinoethoxy)acridine; CL 246738; CL 248738; CL-246,738; CL-246.738; CL-248.738; CL-248738; Acridine, 3,6-bis(2-(1-piperidinyl)ethoxy) trihydrochloride

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride: 3

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 11/01/1989 - "In conclusion, no immunological effects were identified following the administration of CL 246738 in human subjects with recurrent or residual colorectal cancer." 11/01/1989 - "A phase I study of immunostimulation and toxicity in patients with colorectal carcinoma using the immunomodulator 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride (CL 246738)."
2.	Neoplasms (Cancer) 02/01/1990 - "Biological and clinical effects of the oral immunomodulator 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride in patients with malignancy." 07/01/1985 - "Induction of tumor-inhibitory macrophages with a novel synthetic immunomodulator, 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride (CL 246,738)."

Related Drugs and Biologics

1.	Immunologic Factors (Immunomodulators)
2.	Acridines