aminoglycoside N(3')-acetyltransferase

catalyzes the reaction of CoA & acetyl-2-deoxystreptamine antibiotic to yield acetyl-CoA & a 2-deoxystreptamine antibiotic; has broad specificity; acts on gentamicin, tobramycin, sisomicin, netilmicin, kanamycin, neomycin & apramycin

Also Known As:

AAC(3)-IV; aminoglycoside-(3)-N-acetyltransferase IV

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Acetyltransferases: 1040
        aminoglycoside N(3')-acetyltransferase: 2

Experts

1.	Gong, Daojun: 1 article (01/2022)
2.	Hu, Liqing: 1 article (01/2022)
3.	Huang, Junwei: 1 article (01/2022)
4.	Wu, Lin: 1 article (01/2022)
5.	Zhu, Jianjun: 1 article (01/2022)
6.	Zhu, Yongze: 1 article (01/2022)

Related Diseases

1.	Community-Acquired Infections 09/29/2023 - "The most frequently expressed genes among strains isolated from hospital- and community-acquired infections were adhesion-type, ycfm (80%), mrkD (51.3%), and fimH (30.7%); iron uptake, irp2 (84%), fyuA (68.7%), entB (64.7%), and irp1 (56.7%); and protectins, rpmA (26%), which were related to antibiotic-resistance genes, blaTEM (96%), blaSHV (64%), blaCITM (52.6%), blaCTXM-1 (44.7%), tetA (74%), sul1 (57.3%), aac(3)-IV (40.7%), and aadA1 (36%). "
2.	Infections 01/01/2022 - "Here, we report the whole genome sequence of an ST167 clinical isolate (EC16), obtained from a patient with abdominal infection in China, coharbouring the blaNDM-5, blaCTX-M-55, fosA3, aac(3)-IV, and qnrS1 genes. "

Related Drugs and Biologics

1.	Iron