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N-methyllevallorphan
RN given refers to iodide
Also Known As:
N-methyllevallorphan iodide; N-methyllevallorphan methanesulfonate; SR 58002; SR 58002 C; SR-58002; SR-58002 C
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Opiate Alkaloids: 5944
Morphinans: 33
Levallorphan: 30
N-methyllevallorphan: 3
Bridged-Ring Heterocyclic Compounds
Morphinans: 33
Levallorphan: 30
N-methyllevallorphan: 3
Fused-Ring Heterocyclic Compounds
4 or More Rings Heterocyclic Compounds
Morphinans: 33
Levallorphan: 30
N-methyllevallorphan: 3
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Phenanthrenes: 27
Morphinans: 33
Levallorphan: 30
N-methyllevallorphan: 3
Related Diseases
1.
Diarrhea
01/01/1988 - "
In morphine-dependent rats SR 58002 C (0.25, 1, 4 and 32 mg/kg s.c.) induced diarrhea, dose-dependently, in most animals within the first 30 min, while jumping, measured in the same rats, occurred in some animals, not dose-dependently, from 60 min on.
"
12/15/1986 - "
These results further support the remarkable selectivity for peripheral opioid receptors of SR 58002 C, even after repeated high-dose treatment, and are strongly consistent with the primary role of a local intestinal mechanism in the development and expression of opioid withdrawal diarrhea in mice.
"
12/15/1986 - "
in combination with repeated morphine as above, mice which had received naloxone with morphine presented virtually no diarrhea or jumping upon naloxone challenge; those repeatedly treated with morphine plus SR 58002 C were substantially protected from naloxone-precipitated diarrhea, but not jumping.
"
12/15/1986 - "
Dissociation of morphine withdrawal diarrhea and jumping in mice by the peripherally selective opioid antagonist SR 58002 C.
"
12/15/1986 - "
injection of either naloxone, 25 mg/kg, or the peripherally selective opioid antagonist SR 58002 C (N-methyl levallorphan mesilate), 75 mg/kg. Naloxone provoked jumping and diarrhea in all the animals; mice challenged with SR 58002 C presented no significant jumping but a high frequency of withdrawal diarrhea.
"
2.
Constipation
01/01/1983 - "
SR 58002 and MNph were the most potent (ID50, mg/kg s.c., 3.6 and 3.7) in preventing constipation by s.c.
"
Related Drugs and Biologics
1.
Morphine (MS Contin)
2.
Opioid Receptors (Opioid Receptor)
3.
Narcotic Antagonists (Opioid Antagonists)
4.
Naloxone (Narcan)
5.
Mesylates (Mesylate)
6.
Levallorphan (Lorfan)
7.
Opioid Analgesics (Opioids)