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CM 40907
structure given in first source
Also Known As:
3-(4-hydroxypiperidyl)-6-(2'-chlorophenyl)pyridazine; CM-40907; 4-Piperidinol, 1-(6-(2-chlorophenyl)-3-pyridazinyl)-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridazines: 11
CM 40907: 3
Related Diseases
1.
Seizures (Absence Seizure)
01/01/1992 - "
Both drugs suppressed minimal as well as major seizures in all age groups studied in a dose-dependent manner, SR 41378 being approximately four times more potent than CM 40907.
"
06/01/1985 - "
In the rat CM 40907 suppressed completed kindled amygdaloid seizures and was approximately as active as phenobarbital.
"
11/01/1986 - "
Two amino-phenyl-pyridazine derivatives, SR 41378 and CM 40907, have been reported to antagonize seizures in mice, rats and Papio papio baboons with comparable potencies.
"
01/01/1992 - "
The action of two potential anticonvulsants, CM 40907 (10-50 mg/kg i.p.) and SR 41378 (1.25-20 mg/kg i.p.) against metrazol-induced seizures was studied in rats 7, 12, 18 and 25 days old.
"
06/01/1985 - "
In mice, CM 40907 antagonized electroconvulsive shock and chemically induced seizures with an overall potency comparable to that of carbamazepine and a therapeutic ratio (ED50 rotorod/ED50 electroshock) superior to that of ethosuximide, sodium valproate, phenobarbital and carbamazepine.
"
2.
Myoclonus (Nocturnal Myoclonus)
06/01/1985 - "
In naturally photosensitive Senegalese Papio-papio baboons CM 40907 antagonized myoclonus and cortical paroxysmal discharges.
"
Related Drugs and Biologics
1.
1- (6- (2,4- dichlorophenyl)- 3- pyridazinyl)- 4- piperidinol
2.
Valproic Acid (Depakote)
3.
Phenobarbital (Luminal)
4.
Pentylenetetrazole (Metrazol)
5.
Ethosuximide (Zarontin)
6.
Carbamazepine (Tegretol)
7.
Anticonvulsants (Antiepileptic Drugs)
8.
pyridazine