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monacolin L
isolated from Monascus ruber; structure given in first source
Also Known As:
2H-Pyran-2-one, 6-(2-(1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthalenyl)ethyl)tetrahydro-4-hydroxy-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
monacolin L: 3
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
monacolin L: 3
Experts
1.
Sung, Changkeun
: 1 article (04/2017)
2.
Wang, Qijun
: 1 article (04/2017)
3.
Xu, Baojun
: 1 article (04/2017)
Related Diseases
1.
Neoplasms (Cancer)
04/26/2017 - "
The results showed that a statin, monacolin L, and a red pigment, rubropunctatin, from RYR exhibited very strong cancer cell proliferation inhibitory effects; the rubropunctatin was comparable with anticancer drug cis-platinum, taxol, and 10-hydroxy-camptothecin (HCPT) in their IC50 values.
"
2.
Hypercholesterolemia
11/01/1990 - "
We have investigated the effect of six compactin-related compounds--mevinolin, compactin, ML-236A, monacolin X, monacolin L and dihydromonacolin L--on cholesterol synthesis in human umbilical vein endothelial cells, human small intestine epithelial cells, human hepatoma cell line HEP G2, normal human skin fibroblasts and in skin fibroblasts from a patient with familial homozygous hypercholesterolemia.
"
3.
Hepatocellular Carcinoma (Hepatoma)
11/01/1990 - "
We have investigated the effect of six compactin-related compounds--mevinolin, compactin, ML-236A, monacolin X, monacolin L and dihydromonacolin L--on cholesterol synthesis in human umbilical vein endothelial cells, human small intestine epithelial cells, human hepatoma cell line HEP G2, normal human skin fibroblasts and in skin fibroblasts from a patient with familial homozygous hypercholesterolemia.
"
4.
Dehydration (Water Stress)
01/01/1989 - "
It seems that all monacolin L found later during various treatments of the broth and broth extracts is formed from that precursor via a dehydration reaction.
"
Related Drugs and Biologics
1.
Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
2.
Paclitaxel (Taxol)
3.
Lovastatin (Mevacor)
4.
Cisplatin (Platino)
5.
Cholesterol
6.
rubropunctatin
7.
homocamptothecin
8.
monacolin X
9.
dihydromonacolin L
10.
ML 236A